Navigation Links
St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins
Date:9/18/2008

Researchers have determined how an enzyme that stitches all-important molecular adjustments onto proteins contorts itself to regulate its own function

MEMPHIS, Tenn., Sept. 18 /PRNewswire-USNewswire/ -- St. Jude Children's Research Hospital investigators have gained new insight into how the cell's vast array of proteins would instantly be reduced to a confusion of lethally malfunctioning molecules without a system for proteins to "accessorize" in order to regulate their function.

Just as eyeglasses improve vision, a coat provides warmth or an umbrella wards off rain, cells use a set of proteins called ubiquitin-like proteins (UBLs) as accessories that adapt their function as needed in the cell. Now St. Jude scientists have discovered how the function of a protein called cullin-RING changes when it wears the UBL accessory called NEDD8.

The researcher's findings, published in the Sept. 19, 2008, issue of the journal Cell, reveal that NEDD8 changes the shape of cullin-RING to activate it to perform its function. The researchers found that when NEDD8 attaches, it transforms cullin-RING into a kind of molecular valet that can then attach a different accessory (ubiquitin) onto other proteins to foster the myriad of biochemical reactions that enable life.

"The ubiquitination machinery is critical for the cell's proteins to be able to function as necessary in a given environment. One of the major functions of ubiquitin is to mark a protein for disposal when its job is done," said Brenda Schulman, Ph.D., associate member in the St. Jude Structural Biology and Genetics and Tumor Cell Biology departments and Howard Hughes Medical Institute (HHMI) investigator. "Understanding ubiquitination can give us important knowledge about such biological processes as cell division, embryonic development and immune function." Schulman is the paper's senior author.

"Basic insights into ubiquitination could ultimately have clinical application, becau
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. PEAK Surgical Announces Positive Results From Preclinical Study of PEAK PlasmaBlade(TM) Needle
2. Preliminary Data From Experimental Study Demonstrate Increased Mortality in Stroke Patients Treated With Epoetin Alfa
3. St. Jude Study Finds Treatment With New Drug Might Make Tumor Cells More Sensitive to Therapy
4. Eularis Releases First-Ever Study on ROI of Pre-Launch Named Patient Programmes
5. New Bisphenol A Study Has Limited Capability to Assess Human Health Effects
6. Symposium Highlights Yale Study Indicating Role of AHCC(R) for Immune System Enhancement and as a Promising Cancer Preventative
7. MannKind Reports Positive Data from a Phase 3 Clinical Study of Technosphere Insulin in Type 1 Diabetes
8. Latest RAD001 Study Results Show Further Increase in Time Without Tumor Growth in Patients With Advanced Kidney Cancer
9. AstraZeneca and Targacept Announce Top-Line Results from Phase IIb Study of AZD3480 in Alzheimers Disease
10. Most Cancer Treatment Studies Arent Published, Study Finds
11. Enanta Initiates Phase 1 Study on EDP-322, an Oral Antibiotic With Activity Against Hospital- and Community-Acquired MRSA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... YORK , July 3, 2015  Obsidian HDS, ... - an online service for the management of data ... announced today that PharmaShine now includes the 2014 Open ... for Medicare Services on June 30. The data disclosed ... million transactions between industry and providers totaling $6.49 billion ...
(Date:7/2/2015)... Pharma Major Lupin Limited ... en ZAO "Biocom" en Rusia bajo ciertas condiciones ... Lupin en el mercado farmacéutico de Rusia que ... como uno de los 10 principales mercados farmacéuticos ... de una década, el mercado farmacéutico ruso registró ...
(Date:7/2/2015)... , July 2, 2015 Leading ... to capture critical product and market insights in ... benefits to employee-based studies, it is essential for ... own internal employees to capture critical business-related insights. ... benchmarking firm, Best Practices, LLC, most benchmarked companies ...
Breaking Medicine Technology:New Open Payments (Sunshine Act) Data Now Searchable on PharmaShine 2Lupin adquiere Biocom en Rusia 2Lupin adquiere Biocom en Rusia 3Leveraging Employee Insights to Produce Cutting-Edge Market Research 2
... Systems, Inc. (OTCBB: OXYS) ("OxySure"), the pioneering manufacturer ... "oxygen from powder" technology has announced the Company ... W.W. Grainger, Inc. (NYSE: GWW ) ... In terms of the Agreement, OxySure will ...
... GREENWICH, Conn., March 15, 2012 Timothy C. Tyson, ... has been named President and Chief Operating Officer of ... Clinical Trials Supply Business, Mr. Needleman has been promoted ... Operations. In his new role, Mr. Needleman is responsible ...
Cached Medicine Technology:OxySure Systems Announces Supplier Agreement With Grainger 2OxySure Systems Announces Supplier Agreement With Grainger 3Aptuit LLC Names Stuart E. Needleman as President and Chief Operating Officer 2
(Date:7/3/2015)... ... ... " Selfie on a Stick ” was featured on NewsWatch as part ... to consumers. Amanda Forstrom, a technology expert and special reporter for NewsWatch, conducted the ... , Almost every smartphone has an incredibly powerful camera built into it. And when ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the opening ... located in the Lone Star State. The premium frozen yogurt chain was listed as #22 ... opened June 19 in the Village at Bachman Lake, is located at:, 3701 W. Northwest ...
(Date:7/2/2015)... ... July 02, 2015 , ... Many Fourth of July celebrations will ... Amica Insurance is sharing some tips to promote the proper use of ... go to the emergency room daily with fireworks-related injuries in the month surrounding the ...
(Date:7/2/2015)... ... July 02, 2015 , ... Get ready ... SIGVARIS PERFORMANCE SOCKS. Since the socks were first introduced, they have rapidly been ... popularity has inspired four new, fun shades including: blue, lime, pink and red. ...
(Date:7/2/2015)... N.J. (PRWEB) , ... July 02, 2015 , ... ... ACO and Emerging Healthcare Delivery Coalition met for the late June Web-based session, ... forward with new reimbursement schemes and managing high-risk patients through coordinated care. , ...
Breaking Medicine News(10 mins):Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:sweetFrog Opens 18th Location in the Lone Star State 2Health News:6 Fireworks Safety Tips from Amica Insurance 2Health News:SIGVARIS is Sporting Four Brand New Colors in the Popular PERFORMANCE SOCK Product Line 2Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 2Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 3Health News:ACO Coalition Discusses the Future of Medicare Payments and the Benefits of Providing More Care 4
... persons in the Shangdong province of eastern China have been ... has since been contained, state news agency Xinhua has ... last and another 393 people mostly children were ... the agency said, citing Bao Wenhui, the deputy director of ...
... do not completely control epilepsy, surgery often can, and the ... epilepsy specialists are struggling to get that message to tens ... knife at younger ages. ,Says Dr. Deborah Holder, ... be thought of as a last resort. Now we don't ...
... found that the male impotence drug Viagra may be ... originally developed for the treatment of high blood pressure ... reduces levels of a naturally-occurring compound, cyclic guanine monophosphate ... vital function in a signalling pathway that regulates the ...
... concentrated radio waves appears to be a safe and effective ... that can be a precursor of cancer . ... esophagus, a condition associated with the continued reflux of stomach ... over time. While this condition is relatively common, a small ...
... to completely wipe out wild relatives of plants such as ... by the Consultative Group on International Agricultural Research (CGIAR). ... as many as 61 percent of the 51 wild peanut ... species analyzed could become extinct as the result of climate ...
... respond favorably to the drug temozolomide when used as ... to work best in people missing a certain gene. ... the American Academy of Neurology. ,Researchers studied ... of brain tumor, who were treated with temozolomide chemotherapy ...
Cached Medicine News:Health News:Potential Of Epilepsy Surgeries Are Not Fully Harnessed Say Brain Specialists 2Health News:New Approach to Treating Precancerous Esophagus Condition 2Health News:New Approach to Treating Precancerous Esophagus Condition 3Health News:Climate Change Threatening to Wipe Out Wild Relatives of Key Crops 2
... Professional Diagnostics is a leading provider of ... DFA test menu that includes kits for ... well as miscellaneous conjugates and components. Our ... wide assortment of substrates and kit sizes ...
... Professional Diagnostics is a leading provider of ... DFA test menu that includes kits for ... well as miscellaneous conjugates and components. Our ... wide assortment of substrates and kit sizes ...
... Inverness Medical Professional Diagnostics is a ... extensive IFA and DFA test menu that ... and STDs as well as miscellaneous conjugates ... give you a wide assortment of substrates ...
... Professional Diagnostics is a leading provider of ... DFA test menu that includes kits for ... well as miscellaneous conjugates and components. Our ... wide assortment of substrates and kit sizes ...
Medicine Products: