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St. Jude Study Finds Treatment With New Drug Might Make Tumor Cells More Sensitive to Therapy
Date:9/16/2008

ls lacking ATM, the team reported. The researchers also showed that CP466722 sensitized mouse cells to irradiation, an important finding since the team plans to study this effect in those models.

Finally, the team showed that exposure of HeLa cells to CP466722 for only four hours inhibits ATM sufficiently to enhance the cell's sensitivity to irradiation, and that after the compound's removal, the inhibition was rapidly and completely reversed. This suggested that a drug based on CP466722 might enable clinicians to treat patients with minimal doses for brief periods to achieve the maximum therapeutic effect.

Other authors of this report include Maura Charlton and Robert V. Stanton (Pfizer Research Technology Center, Pfizer Global Research and Development, Cambridge, Mass.).

This work was supported by Pfizer, the National Institutes of Health and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.


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SOURCE St. Jude Children's Research Hospital
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