St. Jude Settles Century-Old Debate on Origin of Mammalian Network of Lymphat... (estinations in the developing body. Prog...)

St. Jude Settles Century-Old Debate on Origin of Mammalian Network of Lymphatic Vessels

Date:10/3/2007

estinations in the developing body. Progenitor cells are parent cells that multiply and give rise to distinct populations of cells with different, specific functions in the body.

"We showed that venous-derived LECs sprout from the lymph sacs, multiply and then migrate to their ultimate destination to give rise to the entire lymphatic vasculature; and that hematopoietic cells do not contribute significantly to this process," said R. Sathish Srinivasan, Ph.D. "Therefore, we concluded that in mammals, such as mice and humans, the lymphatic vasculature arises directly and solely from the embryonic veins." Srinivasan is a postdoctoral fellow in Oliver's laboratory and did most of the work on this project.

Other authors of this study include Miriam Dillard and Oleg Lagutin (St. Jude); Fu-Jung Lin, Sophia Tsai, and Ming-Jer Tsai (Baylor College of Medicine, Houston) and Igor Samokhvalov (Center for Developmental Biology, Kobe, Japan).

This work was support in part by the National Heart, Lung, and Blood Institute, a Cancer Center support grant and ALSAC. Srinivasan is a recipient of a Lymphatic Research Foundation postdoctoral fellowship.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.

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