Navigation Links
St. Jude Identifies the Specific Cell That Causes Eye Cancer, Disproving Long-Held Theory
Date:10/18/2007

they can't divide, and if they try to divide, they undergo cell death," Dyer said. "This is the first time that anyone has shown that under certain conditions, a fully mature and differentiated nerve can undergo cell division and multiply."

The discovery that fully differentiated horizontal interneurons can multiply to form retinoblastoma also challenges the established scientific belief that cancer cells are most aggressive when they are undifferentiated, Dyer said. For example, the leukemic cells of chronic myelogeneous leukemia (CML) are much less aggressive when they are differentiated; and it is generally not aggressive until the tumor cells sustain mutations that block differentiation.

An important implication of this finding is that if researchers were able to alter the activity of certain genes in fully developed neurons, they might be able to trigger them to multiply temporarily and replace the neighboring neurons that were lost as a result of neurodegenerative diseases such as Alzheimer's, Dyer said. "Having nerves duplicate themselves might be more efficient than trying to stimulate nerve replacement by inserting stem cells into the brain, since the existing nerves would already be in the right place to restore missing brain cells," he said. "However, there is still a lot of research required to determine if it is possible to control gene activity to make this approach practical."

Other authors of this paper include Itsuki Ajioka, Rodrigo A. P. Martins, Ildar T. Bayazitov, Stacy Donovan, Samantha Cicero, Kelli Boyd and Stanislav S. Zakharenko (St. Jude); Dianna A. Johnson (University of Tennessee Health Science Center, Memphis) and Sharon Frase (University of Memphis).

This work was supported in part by the National Institutes of Health, the National Cancer Institute, the American Cancer Society, Research to Prevent Blindness, Pearle Vision Foundation, the International Retinal Research Foundation, the Whitehall Foundation, NA
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
2. Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug, AN2690; Findings Published in Science
3. ARRIVE Registry Analysis Identifies Predictors of Stent Thrombosis in Real-World Use of Drug-Eluting Stents
4. Pharmacyclics Identifies Functional Biomarkers for its Novel HDAC Inhibitor and Demonstrates Preclinical Anti-Tumor Activity with Brutons Tyrosine Kinase Inhibitors
5. NIDA Study Identifies Genes That Might Help Some People Abstain from Smoking
6. Rigel Ubiquitin Ligase Program Identifies Molecules With Anti-HIV Activity
7. Study in Cell by Magen BioSciences Co-Founder David E. Fisher Identifies New Roles in Skin Cancer Prevention for Key Tumor Suppressor Protein
8. Targeting Specific Mutations Reveals Promising New Approach to Treating Genetic Disorders; Preclinical Data Published in Nature
9. Cell Genesys Reports GVAX Immunotherapy for Prostate Cancer Induces a Broad, Patient-Specific Antibody Response
10. Pieris Demonstrates Potent Anti-Tumor Activity of a VEGF-Specific Anticalin in Preclinical Studies
11. In New Study, Duloxetine Reduced Non-specific Pain and Emotional Symptoms Associated with Depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... YORK , April 21, 2015 EpiCast ... Summary Sepsis is a life-threatening complication arising from ... the infection damages its own tissues and organs. Anyone ... among children <1 year of age, older ... 2014). Global estimates for the year 2013 showed that ...
(Date:4/21/2015)... -- Inmark,s acquisition of Saf-T-Pak last week positioned Inmark ... Division 6.2.  For over 25 years, Saf-T-Pak has ... on IATA, ICAO, US DOT, Transport Canada, RID/ADR ... were particularly interested in Saf-T-Pak,s proprietary Learning Management ... programs," said David Oyler , Inmark President ...
(Date:4/21/2015)... , 21. April 2015  CorTechs ... die quantitative Analyse des Hirnvolumens freut sich, ... weltweiten Pharmaunternehmen, bekannt geben zu können. Die ... NeuroQuant-Quantifizierungsreports des Hirnvolumens zusammenarbeiten, der die Identifizierung, ... in Patienten mit multipler Sklerose als Ziel ...
Breaking Medicine Technology:EpiCast Report: Sepsis - Epidemiology Forecast to 2023 2EpiCast Report: Sepsis - Epidemiology Forecast to 2023 3Inmark's Acquisition Of Saf-T-Pak Results In Expansion Of Its Dangerous Goods Training Portfolio 2CorTechs Labs kündigt Partnerschaft für die Bereitstellung umfassender Lösungen zur Quantifizierung des Verlustes von Hirnvolumen bei multipler Sklerose an 2
(Date:4/21/2015)... Danvers, MA (PRWEB) April 21, 2015 ... managed mobility services, has been recognized by the Boston ... Massachusetts. The ranking was announced at a recent ... Journal’s annual list of the fastest-growing private companies in ... held businesses in the state that recorded the fastest ...
(Date:4/21/2015)... The report “Dermatitis – ... on the therapeutic development for Dermatitis. ... new targets and MOAs to produce first-in-class ... is available @ http://www.rnrmarketresearch.com/dermatitis-pipeline-review-h1-2015-market-report.html . ... involved in the therapeutic development for Dermatitis ...
(Date:4/21/2015)... CA (PRWEB) April 21, 2015 Edward ... and Arthur “A.G.” Kawamura, former Secretary of the California ... featured speakers for the 2nd Annual GrowRIVERSIDE Conference: The ... , The inclusion of these nationally known experts ... experts, city planners, farmers and others slated to speak ...
(Date:4/21/2015)... Chicago, IL (PRWEB) April 21, 2015 ... the online retailer known for innovation at its healthiest, ... supplements starting May 1st. , At Wojo Nutrition, they’ve ... health seekers with convenient solutions tailored to meet their ... designed to be blended with any beverage, has been ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 Carinsuranceshoppingsource.com ... of analyzing comprehensive auto insurance plans . ... it provides coverage for numerous situations. The coverage limit ... expensive. Comprehensive auto insurance will protect a car against ... , Comparing quotes is no longer difficult and ...
Breaking Medicine News(10 mins):Health News:Wireless Analytics Ranked as 25th Fastest Growing Private Company in Massachusetts 2Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 2Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 3Health News:Dermatitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 4Health News:USDA Under Secretary, former CA Agriculture Director to Address 2nd Annual “GrowRIVERSIDE” Conference in June 2Health News:USDA Under Secretary, former CA Agriculture Director to Address 2nd Annual “GrowRIVERSIDE” Conference in June 3Health News:Wojo Nutrition Announces their Lines of Single Serving Liquid Vitamins will be Available for Purchase online at Abesmarket.com Beginning in May 2Health News:Comprehensive Auto Insurance Is An Important But Complex Policy 2
... supplying 150,000 HIV sufferers with free anti-retroviral drugs by the end ... on Monday . ,"We are close to 110,000 people ... of December when we launch a massive scale-up of the drugs" ... increase would be underwritten by a new batch of funding from ...
... bird flu at the weekend, taking the death toll in the ... official said Monday . ,Indonesia has seen its toll ... first confirmed human deaths occurred here. ,"A boy who ... being positively infected," Ningrum, from the ministry's National Bird Flu Information ...
... Dengue fever killed 30 people in Myanmar in the first six ... latest country in the region to experience a surge in ... ministry official, told the weekly Myanmar Times newspaper that the number ... of this year there have been about 3,000 cases of the ...
... into a skin-care product that would wipe away wrinkles and ... ,The government's team of camel researchers, which has already pioneered ... found cosmetic properties in the hardy mammal's milk. ... a hospital's skin department to study it on 20 people ...
... Scientists at Childrens National Medical Center have demonstrated conclusively ... are instrumental in myelination and remyelination, processes essential to ... , This groundbreaking discovery in mouse models ... enhance healthy brain development and/or brain disease repair in ...
... will only make real breakthroughs in childrens medicine if they ... ,Professor John Warner was speaking today at the ... solely devoted to paediatric clinical research. ,The unit ... Marys Hospital, and it is based next to the hospitals ...
Cached Medicine News:Health News:Indonesia Confirms 81st Bird Flu Death 2Health News:Specific Protein is Instrumental in Myelination 2Health News:Specific Protein is Instrumental in Myelination 3Health News:Experts Need to Include Children in Research 2
... 1-step, hand-held, point-of-care device for the qualitative detection ... The TOX/See device can detect up to ... 3 to 8 minutes and requires only a ... individually packaged to maximize convenience and ease of ...
... is a whole blood formulation designed ... of the most popular glucose meters. ... using a control matrix that closely ... packaged in ready-to-use dropper vials with ...
... the laboratory to verify automatic pipets without purchasing ... Each PVS kit contains six vials of Receiver ... Solution. Using the pipet or dilutor to be ... kit is then returned to Streck for analysis ...
... Cyto-Chex BCT is a vacuum tube ... whole blood samples for immunophenotyping by flow ... maintains the integrity of the white blood ... up to seven days. Patient samples collected ...
Medicine Products: