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St. Jude Gene Study Reveals Basis of Anti-Cancer Drug Resistance in Childhood Leukemia
Date:4/15/2008

hers plan to search for such drug targets. They will also search for subtle genetic differences among patients in the response-related genes in search of inherited genetic differences that might explain gene expression and methotrexate response. Finally, the researchers will explore whether patients who respond poorly to methotrexate have specific gene deletions or other genetic alterations in their leukemia cells that cause such poor response.

The findings broadly confirm the value of such sweeping surveys of gene expression in understanding response to anti-cancer drugs.

"Studies such as these add another piece of evidence that this genome-wide approach is very insightful and helpful and informative," Evans said. "If you simply look for the genes that you think might be important, you are likely to miss a number of genes that are."

Other authors include Deqing Pei, Wenjian Yang, Cheng Cheng, Ching-Hon Pui, Mary Relling, John Panetta and Meyling Cheok (St. Jude); Michael J. Sorich (University of South Australia); Nicolas Pottier (Pole Recherche, France); Leo Kager (St. Anna Children's Hospital, Austria); and Gabriele Stocco (University of Trieste, Italy).

This work was supported by National Institutes of Health grants, a Cancer Center Support Grant, a FM Kirby Clinical Research Professorship from the American Cancer Society and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information,
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SOURCE St. Jude Children's Research Hospital
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