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St. Jude Finds 'Dancing' Hair Cells Are Key to Humans' Acute Hearing
Date:5/7/2008

on."

By finding prestin's role in hearing Zuo and his colleagues may help scientists better understand the mechanisms of hearing loss. "For example, an overdose of aspirin causes a high-frequency hearing loss by inhibiting prestin's function," Zuo said. "Also, there is evidence that many cases of high-frequency hearing loss are caused by defects in the cell's molecular machinery that involves prestin. And two mutations that have been detected in the prestin gene in humans are reported to be associated with deafness."

Other authors of the paper include Xudong Wu , Jiangang Gao and Wendy Cheng (St. Jude); Peter Dallos, Mary Ann Cheatham, Jing Zheng, Charles Anderson and Soma Sengupta (Northwestern University, Evanston, Ill.); and Shuping Jia, Xiang Wang and David He (Creighton University, Omaha, Neb.).

This work was supported in part by The Hugh Knowles Center at Northwestern, the National Institutes of Health and ALSAC. Zuo is a recipient of a Hartwell Individual Biomedical Research Award.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit http://www.stjude.org.


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SOURCE St. Jude Children's Research Hospital
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