Navigation Links
St. Jude Defines Eye Cancer Gene's Role in Retinal Development
Date:1/16/2008

Study provides the foundation for improving understanding of N-myc gene's role in the eyes' growth during fetal development when retinoblastoma forms

MEMPHIS, Tenn., Jan. 16 /PRNewswire-USNewswire/ -- A genetic discovery led by scientists at St. Jude Children's Research Hospital helps answer a long-standing mystery about the eyes of vertebrates, and may translate into a deeper understanding of how genes coordinate the complex process of eye formation and how a rare pediatric eye cancer progresses.

"A series of complex developmental processes must be carefully orchestrated for the eye to form correctly," said Michael Dyer, Ph.D., associate member in the St. Jude Department of Developmental Neurobiology. "One important aspect of this coordination is that retinal thickness be the same, irrespective of eye size. For example, the mouse eye is about 5,000 times smaller than that of the elephant eye, but the retinal thickness in these two species is comparable."

Working with mice, the researchers found that a gene called N-myc coordinates the growth of the retina and other eye structures to ensure the retina has the proper thickness necessary to convert light from the lens into nerve impulses that the brain transforms into images. Until their study, reported in the Jan. 15 issue of "Genes & Development," almost nothing was known about the molecular mechanisms responsible for properly sizing the retina. Dyer is the paper's senior author.

"This represents the first example of a role for a Myc gene in retinal development," Dyer said. "On the basis of our data, we propose that N-myc plays a central role in coordinating retinal proliferation with eye growth during development."

Genes in the Myc family carry out vital roles during prenatal development by regulating the proliferation, size, differentiation and survival of cells. Myc genes are also proto-oncogenes--genes in which a mutation enables them to transform normal cells
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Anesiva Defines Regulatory Pathway for Adlea with FDA
2. Childrens Hospital Cancer Study Finds Adolescents and Young Adults Dont Get Same Access to Cutting-Edge Treatment as Younger Patients
3. Kosan Initiates Phase 2 Trial of Alvespimycin, Second-Generation Hsp90 Inhibitor, in HER2-Positive Metastatic Breast Cancer
4. Interim Analysis Supports Continuation of Cell Genesys VITAL-1 Phase 3 Clinical Trial of GVAX Immunotherapy for Prostate Cancer
5. Nektar Commences Phase 2 Clinical Development Program for NKTR-102 (PEG-Irinotecan) in Colorectal Cancer
6. Exelixis Initiates Phase 1/2 Trial of XL184 in Patients With Non-Small Cell Lung Cancer
7. Marital Status Doesnt Affect Lung Cancer Survival
8. Northwest Biotherapeutics Conducting Ovarian Cancer Clinical Trial With DCVax(R)-L at University of Pennsylvania
9. Progen Provides Update on Phase 3 Clinical Program for PI-88 in Liver Cancer
10. Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers
11. Video: New Results From One of the Worlds Largest Breast Cancer Trials Herald Hope for Thousands of Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... 29, 2014 Electrodes are devices that ... be amplified to diagnose as well as treat ... medical devices facilitate the detection of chemical reactions ... and neurons of the patients. In addition, few ... alternating current to perform minimally invasive surgical procedures. ...
(Date:10/30/2014)... 29, 2014 Hospital stretchers are apparatus ... to another, inside or outside of medical infrastructure ... are also used for several specialized functions such ... emergency platforms. The hospital stretchers market ... future market potential of hospital stretchers globally. The ...
(Date:10/30/2014)... , Oct. 30, 2014 Today Eli Lilly ... of its long-standing technology transfer program to increase the ... in 2003, the effort included Lilly donating manufacturing technology ... China , India ... South Africa – all MDR-TB ,hot spots., ...
Breaking Medicine Technology:Electrodes for Medical Devices Market (Diagnostic Electrodes - ECG, EEG, EMG, ERG and Fetal Scalp Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global Industry Analysis, Size, Share, G 2Electrodes for Medical Devices Market (Diagnostic Electrodes - ECG, EEG, EMG, ERG and Fetal Scalp Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global Industry Analysis, Size, Share, G 3Electrodes for Medical Devices Market (Diagnostic Electrodes - ECG, EEG, EMG, ERG and Fetal Scalp Electrodes, Therapeutic Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) - Global Industry Analysis, Size, Share, G 4Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 3Lilly Shares Insights from Decade-Long Technology Transfer Experience 2Lilly Shares Insights from Decade-Long Technology Transfer Experience 3Lilly Shares Insights from Decade-Long Technology Transfer Experience 4
(Date:10/30/2014)... (HealthDay News) -- When it comes to heart disease, a ... delay care when they have symptoms that spell trouble. ... hospital with a more severe or advanced stage of heart ... Catherine Kreatsoulas, a Fulbright Scholar and research fellow at the ... from the Heart and Stroke Foundation of Canada. In ...
(Date:10/30/2014)... HealthDay Reporter WEDNESDAY, Oct. 29, ... bad for your health, a new study reports. Previous ... strengthen bones and prevent osteoporosis. These benefits to bone health ... of a healthy diet. But this new study found ... or women from bone fractures, and was linked to an ...
(Date:10/30/2014)... 2014 (HealthDay News) -- Americans, opinions about the Affordable ... new study finds. Democratic voters are strongly in ... the researchers. Almost three-quarters of Democrats want the next ... want Congress to implement the current law, while 44 ... Among Independent voters, one-third want the law repealed, ...
(Date:10/30/2014)... – A new standard of care for children facing ... multi-year study published in the latest edition of the ... research, led by John Wagner, Jr., M.D., director of ... University of Minnesota and a researcher in the Masonic ... with acute leukemia and myelodysplastic syndrome who received transplants ...
(Date:10/29/2014)... study has found that certain prostate cancer medications are ... causes in men with congestive heart failure or prior ... findings will help doctors and patients weigh the benefits ... therapy (ADT), which reduces levels of male hormones in ... is a mainstay of treatment for prostate cancer. Despite ...
Breaking Medicine News(10 mins):Health News:Women Often Ignore Signs of Heart Trouble 2Health News:Is Milk Your Friend or Foe? 2Health News:Is Milk Your Friend or Foe? 3Health News:Voters' Views on Obamacare Split Along Party Lines 2Health News:Survival rates in pediatric umbilical cord transplants may indicate a new standard of care 2Health News:Survival rates in pediatric umbilical cord transplants may indicate a new standard of care 3Health News:Prostate cancer medications linked with increased risk of heart-related deaths in men with cardiovascular problems 2
... month long fund raising events to find the cure, ... officially declared November as Tay-Sachs Awareness Month,and encourages all ... the need for research to help find a cure. ... frequently in Ashkenazi Jews, French,Canadians, Louisiana Cajuns, and Irish ...
... breakdown, in the epidermis , , FRIDAY, Nov. 2 (Health ... the biological mechanism by which stress increases susceptibility to ... the basis of the stress," said study author Dr. ... of California, San Francisco, and the VA Medical Center, ...
... Mammography Van Features ... NovationDR Digital System, MALVERN, Pa., Nov. 2 ... digital mammography,system in the U.S. The MAMMOMAT(R) NovationDR, a ... Nevada Cancer Institute,s,(NVCI) new Hope Coach, a mobile digital ...
... Emotional Intelligence could be defined as the capacity to perceive, ... so as to be able to distinguish between emotions and ... actions. One of the important benefits of developing this type ... with others and to face an ever changing social and ...
... LAUREL, N.J., Nov. 2 MedQuist Inc. (Pink,Sheets: MEDQ) ... its,previously-disclosed review of strategic alternatives for the Company, is,evaluating ... best interests of the,Company and its shareholders, in light ... ("Philips") of its decision to proceed,with the sale of ...
... Progen,Pharmaceuticals Limited (ASX: PGL; Nasdaq: PGLA) today ... designation awarded to PI-88 for the,prevention of tumour ... in order to commence the Phase 3 program ... continue with the Special Protocol,Assessment process. The ...
Cached Medicine News:Health News:Governor Strickland Declares November Tay-Sachs Awareness Month 2Health News:Governor Strickland Declares November Tay-Sachs Awareness Month 3Health News:Stress Robs Skin of Antimicrobial Defenses 2Health News:Siemens Rolls Out Its First Mobile Digital Mammography System in the U.S. 2Health News:Siemens Rolls Out Its First Mobile Digital Mammography System in the U.S. 3Health News:Emotional Intelligence and the use of tobacco and cannabis 2Health News:MedQuist Evaluating Whether a Sale of the Company is in the Best Interests of the Company and its Shareholders 2Health News:Progen Update on Phase 3 Clinical Program for PI-88 in Liver Cancer 2Health News:Progen Update on Phase 3 Clinical Program for PI-88 in Liver Cancer 3
... a product comes along that forever raises ... category. The new StealthStation TREON plus Treatment ... Built on the phenomenal success of the ... system in the worldthe new TREON plus ...
... the DigiCat Imager ("DCI") to provide rapid, ... The DCI can measure the cataract and ... objective, appropriate and timely surgical decision can ... technology is especially useful in todays healthcare ...
... Until recently, most patients with age-related macular ... to improve or stabilize with or without ... Lumenis has revolutionized the standard of care ... the Opal Photoactivator especially for use in ...
Eye Bank Specular Microscope. Specular microscope for easy examination of corneal slice extracted from a donor....
Medicine Products: