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Spring Bioscience launches highly sensitive PD-L1 (SP142) antibody, a component of Roche's immunotherapy assay
Date:8/25/2014

PLEASANTON, Calif., Aug. 25, 2014 /PRNewswire/ -- Spring Bioscience (Spring), a member of the Roche Group, today announced the launch of its PD-L1 (SP142) rabbit monoclonal immunohistochemistry (IHC) antibody1. This new PD-L1 clone was developed for Roche/Genentech's anti-PD-L1 (MPDL3280A) immunotherapy development program. The SP142 antibody is a component of the clinical trial assay designed by Ventana Medical Systems, Inc. (Ventana), and used in early and late stage clinical trials for various tumor types including non-small cell lung cancer (NSCLC) and urothelial bladder cancer (UBC).

As pharmaceutical companies continue to research and develop cancer drugs that target the immune system, measuring the amount of PD-L1 protein expressed on tumor cells and tumor-infiltrating immune cells may help assess the efficacy and durability of investigational drugs that inhibit the binding of the PD-L1 protein.

Internal comparison studies performed at Spring demonstrated that the PD-L1 (SP142) antibody outperformed other commercially available PD-L1 antibodies. "As with all IHC antibodies developed by Spring, the SP142 antibody will deliver the high quality and accuracy that clinical researchers need to confidently assess PD-L1 status in tissue samples," said Michael Rivers, GM, Spring Biosience. 

"The development of the PD-L1 (SP142) antibody, with its high degree of sensitivity and specificity, may make this a key component of a future companion diagnostic IHC test for Roche's investigational anti-PD-L1 therapy. As researchers strive to understand the clinical relevance of PD-L1 expression, this clone may offer a superior ability to stain and analyze both tumor and immune cells," said Doug Ward, VP and Lifecycle Leader, Ventana Compaion Diagnostics
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