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Spirit II Results Support Strength of Boston Scientific's Two Drug-Eluting Stent Platforms
Date:3/31/2008

At two years, Company's TAXUS(R) and PROMUS(TM) Stents demonstrate positive

and similar outcomes

NATICK, Mass. and CHICAGO, March 31 /PRNewswire-FirstCall/ -- Boston Scientific Corporation (NYSE: BSX) today welcomed positive two-year results from Abbott's prospective, randomized (3:1), single blind, non-inferiority SPIRIT II Trial comparing the safety and efficacy of the XIENCE(TM) V (PROMUS(TM)) Everolimus-Eluting Coronary Stent and Boston Scientific's worldwide market-leading TAXUS(R) Express2(TM) Paclitaxel-Eluting Coronary Stent System ("TAXUS Stent") in 300 patients in Europe. The PROMUS Stent is a private-labeled XIENCE V Everolimus-Eluting Coronary Stent System manufactured by Abbott and distributed by Boston Scientific. Boston Scientific is the only company offering two distinct drugs on two deliverable platforms - the TAXUS and PROMUS Stents. The results were presented today at the SCAI Annual Scientific Sessions in Partnership with the ACC/i2 Summit in Chicago by Professor Patrick Serruys, M.D., Ph.D., Chief of Interventional Cardiology, Thoraxcenter-Erasmus University Rotterdam, The Netherlands, and the SPIRIT II Principal Investigator.

At two years, results from the SPIRIT II trial demonstrated no numerical difference between the XIENCE V (PROMUS) Stent and the TAXUS Stent in their angiographic outcomes, nor were there statistically significant differences in the clinical outcomes. The cardiac death rate for the XIENCE V (PROMUS) Stent was 0.5 percent and for the TAXUS Stent was 1.4 percent (p=0.45). Myocardial infarction (MI) rates for the XIENCE V (PROMUS) Stent and the TAXUS Stent were 2.8 percent and 5.5 percent (p=0.29), respectively. Ischemia-driven target lesion revascularization (
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SOURCE Boston Scientific Corporation
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