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Spinifex Announces Start of Phase 2 Proof-of-Concept Trial of EMA401 in Postherpetic Neuralgia
Date:9/19/2011

ve seen in our earlier clinical and pre-clinical studies."

Dr Milton Raff (Christiaan Barnard Memorial Hospital, Cape Town, South Africa), Principal Investigator for the Study, said: "Current treatments for postherpetic neuralgia are effective in some patients but a significant proportion either don't respond to therapy and are left with debilitating symptoms or suffer significant side effects. EMA401 offers an entirely novel approach to the treatment of the condition and could represent a valuable new option in an area where there is a clear need for new medicines."

In addition to PHN, Spinifex's clinical program for EMA401 will include studies in other neuropathic pain indications including pain and hypersensitivity in peripheral nerve injury patients, and pain and hypersensitivity in cancer chemotherapy patients. The market for neuropathic pain treatments is expected to continue to increase and is projected to reach US$6.2 billion by 2017. Despite this growth, current therapy needs to be improved as a significant proportion of neuropathic pain patients don't respond to current therapy and these treatments have dose-limiting side effects. As a result, EMA401 is being developed as a potential first-in-class oral treatment for neuropathic pain and related symptoms without central nervous system side effects.

Spinifex Pharmaceuticals

Spinifex Pharmaceuticals is an Australian biotechnology company developing new drug candidates for the treatment and management of pain.

Established in 2005 and based in Melbourne, Spinifex has applied its world-class drug development capabilities to advance product candidates. Its lead product EMA401 is under development as a potential first-in-class oral treatment for neuropathic pain and related symptoms without CNS side effects. Spinifex's Phase 2 program for EMA401 will include clinical trials in a number of neuropathic pain conditions. Spinifex investors are GBS Venture Partners, Brandon Capi
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