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Spherix Announces Post-Hoc Analysis of Phase 3 Trial With D-Tagatose in Diabetes

humans to clarify the mechanism of action of D-tagatose in modulating triglycerides and glucose in the metabolic syndrome.Table 1. Correlations Between Clinical MeasuresHbA1cBMITGHbA1c1






1Values are Pearson product-moment correlation coefficients, p less than or equal to 0.10Table 2. Differences Between CountriesUSAIndiameanmeanpBMI28.3




0.43Units: HbA1c %, BMI kg/m2 , TG mg/dlReferencesBloomgarden ZT, Dodis R, Viscoli CM, Holmboe ES, Inzucchi SE. Lower baseline glycemia reduces apparent oral agent glucose-lowering efficacy: a meta-regression analysis. Diabetes Care. 2006 Sep;29(9):2137-9.

Guilherme,  Adilson, Virbasius, Joseph V., Puri, Vishwajeet and Czech, Michael P. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes, Nature Reviews - Molecular Cell Biology, 2008, 9, 367-377.

Khan, Haseeb Ahmad. Clinical significance of HbA1c as a marker of circulating lipids in male and female type 2 diabetic patients, Acta Diabetologica, 2007, 44(4), 193-200.

Laustsen, P. G. et al. Lipoatrophic diabetes in Irs1-/-/Irs3-/- double knockout mice. Genes Dev. 16, 3213–3222 (2002).

Moitra, J. et al. Life without white fat: a transgenic mouse. Genes Dev. 12, 3168-3181 (1998).

Parks, E.J. 2002. Dietary carbohydrate's effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentrations" British Journal of Nutrition, 87: S247-253.doi:10.1079/BJN/2002544. PMID 12088525.

Shimomura, I. et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 12, 3182-3194 (1998).

Sovik, O., Vestergaard, H., Trygstad, O. & Pedersen, O. Studies of insulin resistance in c

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