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Spherix Announces Positive Phase 2 Study Results
Date:6/24/2009

and without type 2 diabetes. Diabetes Obesity Metab 1999 I 5 285-291)

A dose and time-of-administration study was conducted to verify the dosing plan to be used in the phase 3 trial. It was a randomized, open-label, 3 x 3 factorial design for an instant mashed potato load, and a 2 x 3 factorial design for a glucose load in which each subject participated in 11 separate 2-h meal or glucose tolerance tests. A total of 33 non-diabetic, healthy subjects (18 males and 15 females) aged 18-44 years who had satisfied the screening evaluation were enrolled into the study. Treatment with tagatose, whether it was at a dose of 10 g or 15 g, whether it was taken with or before the meal or glucose load, blunted the rise of plasma glucose (Yongming Lu, Gilbert Levin, Thomas Donner. Tagatose, a New Anti-Diabetic and Obesity-Control Drug. Diabetes, Obesity and Metabolism. 10, 2008, 109-134.)

About Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) is a disease that is characterized by elevated blood glucose in the context of insulin resistance and comparative insulin deficiency. While T2DM is often initially managed by increasing exercise in conjunction with dietary modification, medications are usually needed as the disease progresses. There are an estimated 23.6 million people in the U.S. (7.8% of the population) with diabetes, and 17.9 million cases have been diagnosed. Of the diagnosed diabetes cases, 90% are type 2. As T2DM prevalence rates doubled between 1990 and 2005, the CDC characterized the increase as an epidemic. Customarily considered a disease of adults, T2DM is increasingly being diagnosed in children in correlation to increasing juvenile obesity rates.

About Naturlose

Spherix holds patents on the use of Naturlose as a drug to treat diabetes. Naturlose is D-tagatose, which occurs naturally in small amounts in dairy products. It is a highly solu
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SOURCE Spherix Incorporated
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