Spectrum Pharmaceuticals Announces Presentation of SPI-1620 Data at the AACR-NCI-EORTC International ... (

Spectrum Pharmaceuticals Announces Presentation of SPI-1620 Data at the AACR-NCI-EORTC International Conference

Date:10/24/2007

- SPI-1620 Demonstrates Preclinical Evidence of Significantly Increasing

the Uptake of Anticancer Agents in Tumors

- Phase 1 Dose-Escalation Study to Begin Recruiting Patients Shortly

IRVINE, Calif., Oct. 24 /PRNewswire-FirstCall/ -- Spectrum Pharmaceuticals, Inc., (Nasdaq: SPPI) announced that preclinical data on SPI-1620 was presented today via poster presentations at the International Conference of the AACR-NCI-EORTC on Molecular Targets and Cancer Therapeutics, being held in San Francisco October 22-26, 2007. SPI-1620 is a drug that is being developed for use with chemotherapy.

"SPI-1620 continues to show preclinical evidence of selectively targeting tumors to increase the uptake of anti-cancer agents, and improve their therapeutic index," said Rajesh C. Shrotriya, M.D., President and Chief Executive Officer of Spectrum Pharmaceuticals, Inc. "We believe SPI-1620 may have a broad range of applications for use in conjunction with chemotherapy in the treatment of solid tumors. We expect to begin enrolling patients in a Phase 1 open label, dose-escalation study shortly after we receive IRB approval."

Effect Of SPI-1620 On Tumor Perfusion And Uptake Of Paclitaxel In A Melanoma Model

Tumor bearing animals were randomly grouped to receive either saline or SPI-1620, and received paclitaxel 15 minutes after SPI-1620 was administered. Paclitaxel concentration was determined in the tumor, and in a number of normal tissues.

Mice administered with SPI-1620 increased tumor perfusion by up to approximately 200% from baseline and the effect lasted over 2 hours, compared to no significant change in saline treated mice. SPI-1620 treated mice also had over 5 fold increased concen
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Spectrum Pharmaceuticals Announces Presentation of SPI-1620 Data at the AACR-NCI-EORTC International ...( - SPI-1620 Demonstrates Preclinical...),Health