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Soy-Based S-equol Supplement Reduces Hot Flash Frequency, Muscle And Joint Pain In U.S. Postmenopausal Women
Date:4/24/2012

duce S-equol after eating soy.  The study included 72 percent equol nonproducers and 28 percent equol producers, which represents the previously reported US equol producer ratio.  The investigators randomized the equol producers equally into each of the study's treatment groups. 

No previous studies have reported the effects of either soy isoflavones or S-equol on muscle and joint pain. Recent studies conducted with Japanese postmenopausal women documented that measures of neck or shoulder muscle stiffness improved with daily consumption of 10 mg S-equol supplements, compared to a placebo, as well as reduced the frequency of hot flashes. While muscle stiffness and muscle pain can result from impaired local blood flow and both soy isoflavones and S-equol are thought to affect blood flow, this new study suggests that S-equol may potentially be more effective than isoflavones, Jenks explained.

About S-equol
S-equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman] is a compound resulting -- when certain bacteria are present in the digestive tract -- from the natural metabolism, or conversion, of daidzein, an isoflavone found in whole soybeans. Not everyone can produce S-equol after soy consumption, as the production depends on the types of bacteria present in the large intestine and may be influenced by the amount of soy consumed. About 50 percent of Asians and 20 to 30 percent of North Americans and Europeans, who in general consume less soy than Asians, have the ability to produce S-equol. Evidence from observational studies is emerging that suggests that women have milder menopausal symptoms in those who are S-equol producers compared to nonproducers.  

S-equol binds to the same estrogen receptors as naturally estrogen, with a strong affinity to the estrogen receptor beta.  On binding to these receptors, S-equol mimics some, but not al
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