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Soy-Based S-equol Supplement Reduces Hot Flash Frequency, Muscle And Joint Pain In U.S. Postmenopausal Women
Date:4/24/2012

t relief of hot flashes in menopausal women, based on placebo-controlled studies.

The investigators observed, after eight weeks of treatment, significant reductions occurred from the study start in the women's average daily hot flashes, the study's primary endpoint.  These reductions were comparable for all three S-equol treatment groups, 10, 20 or 40 mg, which ranged from decreases of 3.09 to 3.66 hot flashes daily, to that of the soy isoflavone group, which averaged decreases of 2.92.   The average number of daily hot flashes in all of the participants at the study start was 10.0 +/- 4.03. 

Muscle and joint pain improved significantly for both the 10 and 20 mg doses of S-equol compared with the soy isoflavones (p=0.003 and p=0.005, respectively), based on scores from the Greene Climacteric Scale (GCS), which measures 21 symptoms using 0 to 3 scale, where 0 was 'not at all,' 1 was 'a little,' 2 was 'quite a bit' and 3 was 'extremely,' to produce scores.

"These U.S. data expand on the previous studies in Japanese women and further document that a minimum daily 10 mg dose of S-equol would likely help women by both reducing the frequency of their hot flashes as well as decreasing their muscle and joint pain associated with menopause," said Jenks.

Further, for women who had more than eight hot flashes daily at the study start, both 20 and 40 mg S-equol were significantly better than the soy isoflavones in reducing hot flash frequency (p=0.045 and p=0.001, respectively), while the 10 mg S-equol dose had a strong positive trend (p=0.063), according to a sub-group analysis. This finding suggests that the S-equol supplement might be more useful for the women who have a higher frequency of hot flashes, Jenks said.

Also, more women in the 10, 20 and 40 mg S-equol groups achieved a reduction of 50 percent or more in their hot flash frequency by the study end than in
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