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Soy-Based S-equol Supplement Reduces Hot Flash Frequency, Muscle And Joint Pain In U.S. Postmenopausal Women
Date:4/24/2012

NORTHRIDGE, Calif., April 24, 2012 /PRNewswire-USNewswire/ -- A dose of 10 milligrams (mg) daily of S-equol delivered via a newly developed fermented soy germ-based nutritional supplement is as effective as a standard dose of soy isoflavones at reducing hot flash frequency significantly and is even more effective for relieving muscle and joint pain, according to a peer-reviewed study in US postmenopausal women published in the June Journal of Women's Health, available now as a Fast Track article online ahead of print. 

"This study provides evidence that daily doses of the supplement S-equol, a metabolite of the soy isoflavone daidzein, reduced hot flash frequency and relieved muscle and joint pain in U.S. postmenopausal women. These findings confirm earlier studies in Japanese women documenting S-equol's ability to relieve menopausal symptoms," said Belinda H. Jenks, Ph.D., coauthor of the study and director of Scientific Affairs & Nutrition Education at Pharmavite LLC.  Development and ongoing research of a supplement containing S-equol is conducted by the Saga Nutraceuticals Research Institute of Otsuka Pharmaceutical Co., Ltd.  Pharmavite LLC, the makers of Nature Made® vitamins and minerals, is a subsidiary of Otsuka, which supported the study.

S-equol Supplement Reduces Menopausal Hot Flashes, Muscle and Joint Pain in U.S. Women
Daily doses of the supplement containing 10, 20 or 40 mg of S-equol each reduced the frequency of moderate to severe hot flashes similarly to a 50 mg dose of a soy isoflavone supplement in a double-blinded randomized study involving 102 US postmenopausal women aged 45 to 65 who experienced more than 35 hot flashes weekly when they enrolled. The investigators used a standardized soy isoflavone supplement for comparison in the study because of the scientific consensus that extracts or concentrated soy isoflavones suppor
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