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Sorrento Therapeutics Enters into Antibody and Vaccine Development Alliance for the Prevention and Treatment of Obesity
Date:11/5/2013

SAN DIEGO, Nov. 5, 2013 /PRNewswire/ -- Sorrento Therapeutics, Inc. (NASDAQ: SRNE; Sorrento) announced today that it has entered into an antibody and vaccine development collaboration with The Scripps Research Institute (TSRI) of La Jolla, CA. Under the terms of the agreement, Sorrento obtains an exclusive, worldwide license to TSRI's novel technologies based on ghrelin signaling inhibition for the prevention and treatment of obesity and other metabolic disorders.

A research group at TSRI, led by Dr. Kim Janda, has pioneered innovative technology to combat obesity exploiting antibody-mediated neutralization of ghrelin, a hunger-stimulating peptide hormone and an integral component of the food intake regulation circuit. Dr. Janda's group has demonstrated statistically significant effects, such as reduced food intake and body weight loss, in rodents. The scientific articles detailing these studies were published in the Proceedings of the National Academy of Sciences (PNAS)1,2 and Molecular Pharmaceutics3. The ghrelin peptide analogs described by the TSRI team represent a unique opportunity for Sorrento to utilize its proprietary G-MAB® antibody library technology to identify fully human antibodies for the sequestration of ghrelin-mediated appetite process. Sorrento intends to develop vaccines and antibody-based therapeutics to fight obesity.

"Our colleagues at TSRI have presented promising animal data and we are pleased to collaborate on the development of human vaccines and fully human antibody therapeutics to help address this important public health issue. This discovery program represents a novel approach to combating obesity," said Dr.

SOURCE Sorrento Therapeutics, Inc.
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