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Sorrento Awarded Grant from the National Institutes of Health for the Development of a Small Molecule Myc Inhibitor
Date:7/21/2014

r is Dr. Kim D. Janda at The Scripps Research Institute (TSRI), a world-renowned chemical biologist and expert in PPI inhibitors. Earlier this year, Sorrento obtained an exclusive license from TSRI to the Myc inhibitors, the scientific foundation for this program.

Dr. Peter K. Vogt, EVP, CSO, & Professor at TSRI, co-discoverer of the Myc, jun, PI3K, & src oncogenes, and Sorrento's collaborator on this project noted that "Myc has also been called the 'emperor of oncogenes'. Targeting Myc with a small molecule inhibitor has been a daunting challenge and has given rise to the current dogma that Myc is 'undruggable'. Numerous studies have strengthened Myc's candidacy as a promising cancer drug target and also suggest that Myc inhibition might be therapeutic in many or most cancer types, irrespective of the underlying driving oncogenic mechanism. This clearly enhances the significance and importance of this potential scientific breakthrough." The scientific details of these Myc inhibitors will be published in a forthcoming manuscript submitted by Dr. Janda, Dr. Vogt and their TSRI colleagues.

"While Sorrento's focus will remain on developing our clinical stage assets Cynviloq™ and resiniferatoxin (RTX) as quickly and efficiently as possible, government-sponsored research allows us to explore innovative anti-cancer strategies, such as this potentially first-in-class Myc inhibitor. Our academic collaborators at TSRI and Sorrento's research team will perform the preclinical studies needed to bring this program to an inflection point. We are very grateful for NCI's support of this exciting and potentially paradigm-shifting program," said Henry Ji, Ph.D., President and CEO of Sorrento.

About Sorrento Therapeutics, Inc. 
Sorrento is an oncology company developing new treatments for cancer and associated pain. Sorrento's most advanced asset Cynvi
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SOURCE Sorrento Therapeutics, Inc.
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