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Sorbent Therapeutics Presents CLP1001 Phase 2a Study Results at the 16th Annual Meeting of the Heart Failure Society of America
Date:9/10/2012

ct of CLP1001 over eight weeks in 111 heart failure patients with chronic kidney disease (CKD). 

CLP1001-treated patients achieved significantly greater weight loss – an accepted measurement of fluid retention – as compared to placebo over the first two weeks of treatment.  This trend continued through the end of the study.  After eight weeks of treatment, a greater number of patients experienced marked or moderately improved breathing in the CLP1001 group, and the average distance walked in the 6-Minute Walk Test was larger in patients receiving CLP1001 versus the placebo population.  CLP1001 improved functional heart capacity as assessed by the New York Heart Association (NYHA) classification by at least one class compared to the placebo group (48.8% vs. 17.4%; p=0.002).  Similar results favoring the CLP1001 group were seen when examining quality of life.

These data were presented in a talk titled "A Phase 2, Randomized, Double-Blind, Multi-Center Placebo-Controlled Study of a Cross-Linked Polyelectrolyte (CLP vs. Placebo in Heart Failure Patients with Chronic Kidney Disease)". 

About Heart Failure

Heart failure is a progressive condition in which the heart muscle becomes weakened after injury, most commonly caused by heart attack or high blood pressure, and gradually loses its ability to pump enough blood to supply the body's needs.  Many people are not aware they have heart failure because the symptoms are often mistaken for signs of getting older.  Heart failure affects approximately 5.8 million individuals in the United States annually.  Demographic and clinical evidence strongly suggests that the prevalence of heart failure will increase throughout the next decade.  Despite available therapies, heart failure is the most common cause of hospitalizations in patients 65 years and older in the U.S.

About CLP1001

CLP1001 is a non-absorbable, super-absorbent c
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SOURCE Sorbent Therapeutics
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