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Sorbent Therapeutics' CLP1001 Improves Heart Failure Symptoms In Phase 2 Clinical Study
Date:5/22/2012

SUNNYVALE, Calif. and BELGRADE, Serbia, May 22, 2012 /PRNewswire/ -- Sorbent Therapeutics, Inc. a biopharmaceutical company developing therapies for cardiovascular and renal diseases, presented positive data from its Phase 2a clinical study of CLP1001.  In the study of 111 heart failure patients with chronic kidney disease, CLP1001 demonstrated improvement in heart failure symptoms as compared to placebo.   

Data from the randomized, double-blind Phase 2a study were presented in an oral session at the Annual European Society of Cardiology Heart Failure Congress 2012 in Belgrade, Serbia.  A manuscript detailing the results of the Phase 2a clinical study, titled "A Double-Blind, Randomized, Parallel, Placebo Controlled Study Examining the Effect of Cross-linked Polyelectrolyte (CLP) in Heart Failure Patients with Chronic Kidney Disease," will be published in the June 2012 issue of the European Journal of Heart Failure.

"Addressing the symptoms of heart failure is critically important to patients' quality of life.  The beneficial effects of CLP1001 represent a meaningful improvement in heart failure signs and symptoms in a difficult-to-treat patient population," said Maria Rosa Costanzo, M.D., F.A.C.C., Medical Director of the Edward Center for Advanced Heart Failure in Naperville, Illinois and member of Sorbent's Medical Advisory Board.  "I am excited by the data obtained from this trial and look forward to CLP1001's continued clinical development in heart failure."

"Despite available therapies, heart failure is the most common cause of hospitalizations in patients 65 years and older in the U.S.  The positive findings from this Phase 2a clinical study of CLP1001 are highly promising with regard to reducing fluid retention and shortness of breath, which are considered critical measures of success in the treatment of heart failure patients," said Howard C. Dittrich, M.D., F.A.C.C., Sorbent's Chief Medical
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