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Soliris(R) Improved Fatigue Independent of Changes in Anemia in Patients with PNH by Controlling Hemolysis
Date:6/14/2008

ude disabling fatigue," said Dr. Hill. "The data presented at EHA help us to understand that fatigue in PNH is tied much more closely to hemolysis than to anemia, and emphasize the importance of eculizumab therapy in providing a better quality of life to patients with PNH, independent of any changes in anemia they experience."

Soliris, developed by Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN) was approved in the U.S. and European Union in 2007; Soliris is indicated in the U.S. for the treatment of patients with PNH to reduce hemolysis and is indicated in the EU for the treatment of patients with PNH. PNH is a rare, debilitating and life-threatening blood disease in which hemolysis, caused by the patient's own immune system, can cause thromboses (blood clots), disabling fatigue, anemia, impaired quality of life, shortness of breath, recurrent pain, kidney disease and intermittent episodes of dark-colored urine (hemoglobinuria). (2-4)

Soliris, Hemolysis and Fatigue in PNH

Fatigue levels in patients with PNH are often severe and similar to those experienced by anemic cancer patients. Soliris has been shown to reduce substantially the frequently disabling fatigue associated with PNH. The data presented today provide additional insight into the mechanism through which Soliris positively impacts PNH-related fatigue. While treatments designed to improve anemia can improve fatigue in both PNH and cancer, these data demonstrate that fatigue in PNH is also related directly to chronic hemolysis and can be improved independent of correction of anemia. Soliris has also been associated with other significant benefits in patients with PNH, including reduction in hemolysis and reduction in thrombotic events during treatment phase compared t
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SOURCE Alexion Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
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1. Alexion Completes Enrollment in AEGIS Registration Study of Soliris(R) (eculizumab) in Patients with PNH in Japan
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3. PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity
4. Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH
5. Soliris(R) Demonstrates Reductions in Hemolysis and Improvements in Fatigue, Overall Quality of Life and Anemia in a Broad Population of PNH Patients
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