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Soliris(R) Improved Fatigue Independent of Changes in Anemia in Patients with PNH by Controlling Hemolysis
Date:6/14/2008

Data Suggest Role of Hemolysis in PNH-Related Fatigue

Presentation at the European Hematology Association 13th Congress

CHESHIRE, Conn., June 15 /PRNewswire-FirstCall/ -- Soliris(R) (eculizumab) therapy improved the often disabling fatigue experienced by patients with the rare blood disorder paroxysmal nocturnal hemoglobinuria (PNH) independent of improvements in anemia, according to data presented today at the European Hematology Association (EHA) 13th Congress in Copenhagen (abstract number 0903). These data suggest that fatigue experienced by patients with PNH is related directly to hemolysis -- the red blood cell destruction that defines the disease -- and can be improved independent of correction of anemia.

In clinical trials with Soliris, PNH patients experienced a substantial improvement in PNH-related fatigue independent of changes in their anemia. This improvement was larger than the improvement in fatigue reported in a separate study of anemic cancer patients treated with erythropoietin (EPO). Furthermore, in contrast to the improvement in fatigue of anemic cancer patients treated with EPO which occurred only when anemia was also improved, Soliris-treated PNH patients experienced improvements in fatigue independent of changes in their anemia. Taken together, these data suggest that hemolysis likely contributes to fatigue experienced by patients with PNH independent of the contribution of hemolysis to anemia in these patients.

The data were highlighted in an oral presentation to the EHA Congress by Anita Hill, MB, ChB, Consultant Hematologist at Bradford Teaching Hospitals, UK, lead author of the abstract titled, "Improvement in Fatigue with Eculizumab Treatment of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Occurs Independent of Changes in Anemia." (1)

"Complement-mediated hemolysis is the defining characteristic of PNH and the cause of the serious clinical consequences of the disease, which incl
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SOURCE Alexion Pharmaceuticals, Inc.
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1. Alexion Completes Enrollment in AEGIS Registration Study of Soliris(R) (eculizumab) in Patients with PNH in Japan
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4. Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH
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