Navigation Links
Soliris(R) Demonstrates Reductions in Hemolysis and Improvements in Fatigue, Overall Quality of Life and Anemia in a Broad Population of PNH Patients
Date:12/4/2007

te Professor of Medicine and Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University School of Medicine. "The improvements in symptoms and signs of this debilitating disease were observed irrespective of baseline levels of hemolysis and degree of thrombocytopenia. Importantly, SHEPHERD encompassed a broad group of patients who are typical of the type of patients that are seen day to day in practice."

SHEPHERD examined the safety and efficacy of eculizumab in a broader, more diverse population of PNH patients than the TRIUMPH study by allowing enrollment of patients with minimal transfusion requirements and/or evidence of thrombocytopenia to enter the trial. A total of 69 patients (71%) in the SHEPHERD study would not have met the inclusion criteria for entry into the companion Phase III double-blind placebo-controlled TRIUMPH trial.(4)

Clinical Data

The online publication in Blood, titled "Multicenter phase III study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria" reported data from the 97 patients, enrolled at 33 international sites, studied in the non-placebo controlled open-label Soliris Phase III SHEPHERD trial. The primary efficacy endpoint in this 52-week, open-label study was hemolysis, as measured by serum lactate dehydrogenase (LDH) levels. LDH is released during red blood cell destruction. Every patient treated with Soliris had a substantial reduction in hemolysis as measured by levels of LDH. LDH was reduced from a mean of 2201 plus or minus 105 U/L at baseline to 297 plus or minus 21 U/L at 52 weeks (P < 0.001).

"In addition to the universal improvement in hemolysis, patients in SHEPHERD experienced significant improvements in fatigue, overall quality of life, and anemia," said Leonard Bell, M.D., chief executive officer of Alexion. "For many patients, treatment with Soliris results in life-changing improvements in daily living. The bene
'/>"/>

SOURCE Alexion Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Cytokine Demonstrates Oral Efficacy of Small-Molecule MIF Inhibitors
2. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
3. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
4. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
5. Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety
6. Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process
7. R7128 Demonstrates Safety and Potent Antiviral Activity in HCV-Infected Patients
8. Rochester Medical Anti-Infection Foley Catheter Demonstrates Effectiveness in Randomized Trial
9. New Study Demonstrates 4 Year Olds Fed Enfamil LIPIL(R) as Infants Have Brain and Eye Outcomes Similar to Breastfed Babies
10. ACTOS(R) (pioglitazone HCl) Demonstrates Reduced Risk of Ischemic Cardiovascular Disease in Patients with Type 2 Diabetes
11. Oritavancin Demonstrates Superior In Vitro Activity to Vancomycin and Metronidazole Against C. Difficile Bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Aug. 29, 2014 Medina Medical announced today ... member of the Board of Directors on August 18, ... development and commercialization experience, including over a decade of ... served as a Partner of the medical device incubator ... of two Foundry start-ups. Mr. Engelson previously served as ...
(Date:8/29/2014)... Aug. 29, 2014 Research and Markets ... Peptide Cancer Therapeutics Market & Pipeline Insight 2014" ... methods developed to prevent and eradicate the prevalence of ... methods are confined to low specificity, safety and large ... look for a better solution. It has been discovered ...
(Date:8/29/2014)... Aug. 29, 2014 Research and Markets ... and Development Trend Forecast of Pharmaceutical Equipment Market in ... Research and Development Trend Forecast of Pharmaceutical Equipment ... analyzes China,s pharmaceutical equipment industry ... demand, competition landscape, and business performance of domestic major ...
Breaking Medicine Technology:Medina Medical Announces Erik T. Engelson Joins as Chief Executive Officer 2Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2
(Date:8/30/2014)... Pittsburgh, PA (PRWEB) August 30, 2014 ... the result of a car accident," said one of ... constant muscle strain in her shoulder and neck area. ... we invented reduced pain and pressure, assisting in comfort ... for the patent-pending PILLOW CRADLE to support the head, ...
(Date:8/30/2014)... Texas (PRWEB) August 30, 2014 ... Oven Industry, 2009-2019 is a professional and in-depth ... industry. The report firstly reviews the basic information ... manufacturing technology. The report then explores global and ... product specification, capacity, production value, and market share ...
(Date:8/30/2014)... Serving contented clients since inception, #1 web ... is now offering discount for Labor Day on ... on putting forward the best of web development technology ... team of professionals and web developers and designers has ... the critical issues of web development and can develop ...
(Date:8/30/2014)... York, New York (PRWEB) August 30, 2014 ... litigation for transvaginal mesh lawsuits ( http://www.injurybeacon.com/transvaginal-mesh/ ) ... company’s request to sever four cases selected for ... an Order issued on August 18, 2014, U.S. ... District of West Virginia disagrees with Boston Scientific’s ...
(Date:8/30/2014)... 2014: Transvenous lead extraction (TLE) is clinically successful in ... the European Lead Extraction ConTRolled (ELECTRa) registry presented for ... Dr Maria Grazia Bongiorni, chair of the registry,s executive ... implantable electronic devices (CIED) implant procedures has grown in ... complications has increased and leads are often the cause. ...
Breaking Medicine News(10 mins):Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 2Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 3Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 4Health News:Profit By Outsourcing Offering Discount for Labor Day on all Web Development Services 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:Transvenous lead extraction clinically successful in 98 percent of cases 2Health News:Transvenous lead extraction clinically successful in 98 percent of cases 3
... VNUS(R) Medical,Technologies, Inc. (Nasdaq: VNUS ), a leading provider ... disease,announced today that it plans to report its financial results ... of market on July 29., VNUS plans to host ... ET on July 29. This call will be webcast live ...
... 14 In response to last week,s,widely reported story ... government for services prescribed by dead physicians,Patrick O,Connell of ... the Texas,Attorney General,s Civil Medicaid Fraud Section, has called ... in the prosecution,of such cases., "This is a ...
... Pennsylvania, 90 percent of Medicaid LTC funds for ... 14 A new report by AARP,s,Public Policy ... state,government efforts to balance long-term care (LTC) options ... states spent more than 50,percent of their Medicaid ...
... Successful and Timely Program ... Implementation, ... selection by the Centers for Medicare & Medicaid Services,(CMS) of the ... 325 medical equipment suppliers nationwide to serve Medicare,beneficiaries under its Competitive ...
... 14 Preliminary findings,from a landmark independent, ... released today at the Project Management Institute,s ... organizational,performance can be significantly improved through the ... the Value of Project Management," is,"unequivocal in ...
... Billups of the Detroit Pistons, DETROIT, July 14 ... Annual Celebrity Golf Classic is just around the,corner on ... The day is sure to be fun and ... shotgun start at 11:00 a.m. Highlights of the,event include ...
Cached Medicine News:Health News:VNUS Medical Technologies to Report Second-Quarter 2008 Results and Webcast Teleconference on July 29 2Health News:Government Ill-Equipped to Prevent Medicaid Fraud, Says False Claims Act Expert 2Health News:New AARP Report Finds Older Americans Have Limited Access to Home and Community-Based Services Under Medicaid 2Health News:All-Med Services of Florida Awarded Medicare Competitive Bidding Contract 2Health News:Study: Global Business Performance Significantly Improved Through Project Management 2Health News:Come Tee-Up at The Children's Center 24th Annual Celebrity Golf Classic! 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: