Navigation Links
Soligenix Submits NIAID Contract Proposal for Development of a Thermostable Ricin Vaccine
Date:10/31/2013

formulations using adjuvants, protein immunogens, and other components that ordinarily would not withstand long temperature variations exceeding customary refrigerated storage conditions. These studies were conducted with our aluminum-adjuvanted ricin toxin vaccine, RiVax™, made under precise lyophilization conditions using excipients that aid in maintaining native protein structure of the ricin A chain, the immunogenic compound of the vaccine. When RiVax™ was kept at 40 degrees Celsius for six months, all of the animals vaccinated with the lyophilized RiVax™ vaccine developed potent and high titer neutralizing antibodies. Confirmatory results have extended the stability to six months when the vaccine is kept at 40 degrees Celsius. In contrast, animals that were vaccinated with the liquid RiVax™ vaccine kept at 40 degrees Celsius did not develop neutralizing antibodies and were not protected against ricin exposure. The ricin A chain is extremely sensitive to temperature and rapidly loses the ability to induce neutralizing antibodies when exposed to temperatures higher than 8 degrees Celsius.

The underlying lyophilization technology was discovered by Drs. John Carpenter and Theodore Randolph at the University of Colorado, the inventors of the technology underlying the ThermoVaxTM products. 

About Ricin Toxin

The Centers for Disease Control has classified ricin toxin as a Category B biological agent. Currently, there are no FDA approved therapeutics or vaccines that can be used to protect against ricin exposure or to reverse its effects once exposed. Ricin toxin is a protein that consists of an A and B subunit that can be extracted from the beans of the castor plant, Ricinus communis. The potential use of ricin toxin as a biological weapon of mass destruction has been highlighted in an FBI Bioterror report released in November 2007, entitled
'/>"/>

SOURCE Soligenix, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Soligenix Announces Further Progress with ThermoVax™ for Long-Term Vaccine ThermoStability
2. Soligenix Reports First Quarter 2012 Financial Results and Highlights Recent Accomplishments
3. Soligenix Reports Second Quarter 2012 Financial Results and Highlights Recent Accomplishments
4. Soligenix Announces Issuance of US Patent for Topically Active Steroids to Treat Inflammatory Gastrointestinal Disorders
5. FDA Grants Soligenix Fast Track Designation for SGX203 for the Treatment of Pediatric Crohns Disease
6. Soligenix Reports Third Quarter 2012 Financial Results and Highlights Recent Accomplishments
7. FDA Grants Soligenix Fast Track Designation for OrbeShield(TM) for the Reduction of Mortality Associated with Gastrointestinal Acute Radiation Syndrome (GI ARS)
8. Soligenix Announces Formation of Oral Mucositis Medical Advisory Board
9. Soligenix to Present at 15th Annual BIO CEO & Investor Conference
10. Soligenix Receives IND Clearance from FDA to Initiate Clinical Program to Evaluate SGX942 for the Treatment of Oral Mucositis
11. Soligenix to Present at World Vaccine Congress & Expo
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... 2015 Edwards Lifesciences Corporation (NYSE: EW ), ... hemodynamic monitoring, today announced that Robert A. Ingram ... "Bob is an ardent champion for innovation in the lifesciences ... him on Edwards, board as we pursue our focused innovation ... CEO.  "Bob has provided a valuable perspective to our board, ...
(Date:7/30/2015)... Inc. (NYSE: RMD ) today announced results for ... quarter was $453.1 million, a 9 percent increase compared ... percent increase on a constant currency basis).  Net income ... 30, 2014.  Diluted earnings per share for the quarter ... 2014.  The results for the quarter ...
(Date:7/30/2015)... , July 30, 2015  Unichem Pharmaceuticals ( ... one lot of Hydrochlorothiazide tablets 25 mg 1000-count bottle ... as a precautionary measure due to the identification of ... product. The risk associated with mistakenly ... is the increased probability of experiencing Clopidogrel,s side effects ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2
... new white paper urges medical device and combination product ... as a means of preventing the failure of ... medical products are based on years of data that ... occur due to inadequate package validation programs," said Steven ...
... 16, 2010 Reportlinker.com announces that a new ... Global Analgesics Industry ... the worldwide markets for Analgesics in US$ Million ... Ibuprofen, and Others (includes combination drugs)), and External ...
Cached Medicine Technology:New White Paper: Having a Solid Package Validation Program Can Prevent Failure of Combination Products 2New White Paper: Having a Solid Package Validation Program Can Prevent Failure of Combination Products 3Reportlinker Adds Global Analgesics Industry 2Reportlinker Adds Global Analgesics Industry 3Reportlinker Adds Global Analgesics Industry 4Reportlinker Adds Global Analgesics Industry 5Reportlinker Adds Global Analgesics Industry 6Reportlinker Adds Global Analgesics Industry 7Reportlinker Adds Global Analgesics Industry 8Reportlinker Adds Global Analgesics Industry 9Reportlinker Adds Global Analgesics Industry 10Reportlinker Adds Global Analgesics Industry 11Reportlinker Adds Global Analgesics Industry 12Reportlinker Adds Global Analgesics Industry 13Reportlinker Adds Global Analgesics Industry 14Reportlinker Adds Global Analgesics Industry 15Reportlinker Adds Global Analgesics Industry 16Reportlinker Adds Global Analgesics Industry 17Reportlinker Adds Global Analgesics Industry 18Reportlinker Adds Global Analgesics Industry 19Reportlinker Adds Global Analgesics Industry 20Reportlinker Adds Global Analgesics Industry 21
(Date:8/1/2015)... ... August 01, 2015 , ... Brig and Lita Hart, icons of the network ... their Healthy Home mission with the HOPE Movement of EvolvHealth. In what has been ... companies have agreed to join their missions of purpose together to change the course ...
(Date:8/1/2015)... (PRWEB) , ... August 01, 2015 , ... Lume Wellness ... that is free to download on the Apple AppStore. , The app is ... even mood, thus acting as a tool to view personal health and use this ...
(Date:8/1/2015)... ... 2015 , ... On March 19, 2015 Phil Valentine – the Executive Director of Connecticut Community ... by stepping off Springer Mountain and heading north. Since that day, Phil has hiked ... and was greeted by friends and family. He visited CCAR and left an inspirational ...
(Date:7/31/2015)... ... July 31, 2015 , ... When the weather turned hot ... their new type of sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) ... To commemorate introduction of this new type of sod, Super-Sod is giving away red ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source for ... Chicago at Grant Park. The festival will end on Sunday, August 2nd. ... for the annual Lollapalooza. This unique and unbelievably popular festival attracts the best ...
Breaking Medicine News(10 mins):Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2
... 20 Progen Pharmaceuticals Limited (ASX: PGL; Nasdaq: ... its epigenetic technology successfully inhibits tumor growth.The results ... at the 100th Annual American Association for Cancer ... in ,switching on, important anti-cancer genes - a ...
... April 20 A new alliance between the ... leading manufacturer of unattended massage beds is focused ... a new and affordable service to customers.(Photo: ... Enterprises manufactures the HydroMassage, a massage system that ...
... the University of Southern California have identified a new ... surrounding blood vessels without the negative side effects typically ... 2.5-dimethyl-celecoxib (DMC) appears to have a strong anti-tumor effect ... supply necessary for tumor growth, according to data presented ...
... Fluorescent Channels to Enable Greater Data Ranges and Multiplexing ... Series Launched to Enable Imaging, Co-Registration and Data Fusion ... April 20 VisEn Medical Inc., a ... research through medicine, announced that users of its FMT ...
... added everolimus (Afinitor(R), Novartis) to the NCCN Guidelines for ... renal cell carcinoma whose disease has progressed after treatment ... of the March 30, 2009 FDA approval of everolimus ... that the therapy significantly extended progression-free survival in a ...
... Schwabe North America , has announced the ... Way sales teams. The integration marks an exciting ... Inc. by German-based Dr. Willmar Schwabe Pharmaceuticals, a leading ... years.The combined Specialty Retail Field Sales Team will service ...
Cached Medicine News:Health News:Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth 2Health News:Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth 3Health News:Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth 4Health News:ETS Tan Now Exclusive Distributor of HydroMassage in U.S. 2Health News:USC researchers develop new drug to target tumor cells and blood vessels 2Health News:VisEn Medical Launches Expanded FMT 2500(TM) Imaging Platforms at AACR Meeting 2Health News:VisEn Medical Launches Expanded FMT 2500(TM) Imaging Platforms at AACR Meeting 3Health News:NCCN Updates Kidney Cancer Guidelines to Incorporate FDA Approval of Everolimus 2Health News:NCCN Updates Kidney Cancer Guidelines to Incorporate FDA Approval of Everolimus 3Health News:Schwabe North America Integrates Enzymatic Therapy and Nature's Way Sales Teams 2
For regulating sample flow rate when using the QIAvac 24 Plus;...
Holder for QIAGEN 96-well plates, for use with QIAvac 96;...
For connecting the QIAvac 24 Plus and Vacuum Pump;...
For monitoring vacuum pressure, suitable for use with all QIAvac manifolds;...
Medicine Products: