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Soligenix Submits NIAID Contract Proposal for Development of a Thermostable Ricin Vaccine
Date:10/31/2013

AID.  In addition, our organizational structure and experience allows Soligenix to be a valuable strategic partner for NIAID, as well as with the other agencies we currently work with."

The submission of our proposal is non-binding and does not guarantee the award of a NIAID contract.  The contract award will require a favorable technical, scientific and business review by NIAID followed by negotiation of fair and reasonable contract terms.

About RiVax™

RiVax™ is Soligenix's proprietary recombinant subunit vaccine developed to protect against exposure to ricin toxin. With RiVax™, Soligenix is a world leader in the area of ricin toxin vaccine research.

RiVax™ contains a genetically altered version of ricin A chain containing two mutations that inactivate the inherent toxicity of the ricin molecule. The Phase 1A clinical trial was conducted with a formulation of RiVax™ that did not contain an adjuvant. That trial revealed dose dependent seroconversion as well as lack of toxicity of the molecule when administered intramuscularly to human volunteers. The adjuvant-free formulation of  RiVax™ induced toxin neutralizing antibodies that lasted up to 127 days after the third vaccination in several individuals.  To increase the longevity and magnitude of toxin neutralizing antibodies, RiVax™ was formulated with an adjuvant of aluminum salts (known colloquially as Alum) for the Phase 1B clinical trial.  Alum is an adjuvant that is used in many human vaccines, including most vaccines used in infants. In preclinical animal studies, the Alum formulation of RiVax™ induced higher titers and longer lasting antibodies than the adjuvant-free vaccine. 

The development of RiVax™ has been sponsored through a series of overlapping grants from both the NIAID and FDA, which were granted to Soligenix and to UTSW where the vaccine originated. To date, Soligenix and UTSW ha
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SOURCE Soligenix, Inc.
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