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Soligenix Demonstrates Positive Proof of Concept with its Proprietary Vaccine Thermostabilization Technology
Date:2/6/2012

PRINCETON, N.J., Feb. 6, 2012 /PRNewswire/ -- Soligenix, Inc. (OTCBB: SNGXD) (Soligenix or the Company), a development stage biopharmaceutical company, announced today results from preclinical studies of its proprietary vaccine thermostabilization technology indicating that Soligenix is able to produce stable vaccine formulations using adjuvants, protein immunogens, and other components that ordinarily would not withstand long temperature variations exceeding customary refrigerated storage conditions.

These studies were conducted with Soligenix's aluminum-adjuvanted ricin toxin vaccine, RiVax™, made under precise lyophilization conditions using excipients that aid in maintaining native protein structure of the ricin A chain, the immunogenic compound of the vaccine. When RiVax™ was kept at 40 degrees C for over one month, all of the animals vaccinated with the lyophilized RiVax™ vaccine developed potent and high titer neutralizing antibodies. In contrast, animals that were vaccinated with the liquid RiVax™ vaccine kept at 40 degrees C did not develop neutralizing antibodies and were not protected against ricin exposure. The ricin A chain is extremely sensitive to temperature and rapidly loses the ability to induce neutralizing antibodies when exposed to temperatures higher than 8 degrees C.

These studies were performed by Theodore W. Randolph, PhD, Professor of Pharmaceutical Biotechnology at the University of Colorado Boulder and John Carpenter, PhD, Professor of Pharmaceutical Biotechnology at the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of Colorado Anschutz Medical Campus. Dr. Randolph stated, "Early indications from the ongoing stability evaluation of the ricin vaccine stored at elevated temperatures are very encouraging for a protein immunogen that is otherwise so inherently unstable."

"We are very excited about these results as the achievement of extended stability under elevated t
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SOURCE Soligenix, Inc.
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