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Soligenix Announces Publication of Positive Stability Results with RiVax(TM), its Vaccine Against Ricin Toxin
Date:2/2/2010

munogenicity," Vaccine) is available online at http://dx.doi.org/10.1016/j.vaccine.2009.12.081.

About RiVax™

RiVax™ is Soligenix's proprietary vaccine developed to protect against exposure to ricin toxin and is the most advanced vaccine in the company's portfolio. RiVax™ induces a protective immune response in animal models of ricin exposure and is currently being evaluated in humans. One human Phase 1 clinical trial has been completed and a second trial is currently being conducted.

Results of the first Phase 1 clinical trial of RiVax™ indicated that the immunogen was safe and induced antibodies anticipated to protect humans from ricin exposure. The outcome of the study was published in the Proceedings of the National Academy of Sciences (Vitetta et al., 2006, PNAS, 105:2268-2273). The second trial, sponsored by UT Southwestern, is currently evaluating a more potent formulation of RiVax™. Soligenix has developed processes for large-scale manufacturing and is further establishing correlates of the human immune response in non-human primates.

The development of RiVax™ has been sponsored through a series of overlapping challenge grants (UC1) and cooperative grants (U01) from the NIH, granted to Soligenix and to UT Southwestern where the vaccine originated. The second clinical trial is being supported by a grant to UT Southwestern from the US Food and Drug Administration's Office of Orphan Products Development. Soligenix and UT Southwestern have collectively received approximately $25 million in grant funding from the NIH for development of RiVax™ and related vaccine technologies.


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SOURCE Soligenix, Inc.
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