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Soligenix Announces Publication of Positive Stability Results with RiVax(TM), its Vaccine Against Ricin Toxin
Date:2/2/2010

e was also tested for immunogenicity in mouse challenge models, in which vaccinated mice were exposed to ricin by the aerosol or oral route. In each case, the reconstituted vaccine was demonstrably protective in comparison to control vaccine preparations.

"We know that the ricin subunit vaccine itself is very sensitive to denaturation, and we are very encouraged to find lyophilization conditions that aid in the long-term stability of the vaccine," stated Dr. Ellen Vitetta, Director of the Cancer Immunobiology Center at UT Southwestern and an author of the study. "We are also pleased to see that in our study storage for over one year at ambient conditions resulted in no apparent degradation of potency or the integrity of the protein immunogen."

"These results are very promising not only for the future development of RiVax™ in particular, but also for the potential development of other vaccines with long-term stability, especially those using conventional adjuvants composed of aluminum salts," stated Robert N. Brey, Ph.D., Chief Scientific Officer of Soligenix. "Our current efforts are centered on combining conventional adjuvant and scalable lyophilization techniques to examine formulations that retain stability at elevated temperatures, building on the results that Dr. Vitetta and her colleagues have reported in this publication."

The article, entitled "A lyophilized formulation of RiVax™, a recombinant ricin subunit vaccine, retains immunogenicity," was authored by Drs. Joan Smallshaw and Ellen Vitetta at UT Southwestern. The research was funded directly by an NIH grant to UT Southwestern and complements the NIH funding to Soligenix for the development of RiVax™. The full article (Smallshaw and Vitetta, "A lyophilized formulation of RiVax, a recombinant ricin subunit vaccine, retains im
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SOURCE Soligenix, Inc.
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