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Soligenix Announces Publication of Positive Data Describing Protection from Mucosal and Systemic Ricin Intoxication by Intradermal RiVax™ Administration
Date:6/25/2010

fic antibodies, resulting in both systemic and mucosal protection when 90-99% less vaccine was used;
  • Vaccination with RiVax™ adsorbed to aluminum adjuvant via the ID route was significantly better than vaccination via the IM route at protecting animals from ricin challenge, hence, smaller doses of vaccine may be required when ID vaccination is used;
  • In comparing IM vs. ID vaccination with RiVax™  adsorbed to aluminum adjuvant at low doses, the latter was more effective at protecting mice from ricin-induced lung damage; and
  • RiVax™ specific antibody levels correlated with post challenge survival.

  • "There have been many attempts to develop a prophylactic ricin vaccine, using different preparations of the ricin holotoxin with and without various adjuvants," stated Dr. Ellen Vitetta, Director of the Cancer Immunobiology Center at UT Southwestern and senior author of the study.  "But none of these have been as extensively studied as RiVax™ and none have looked at the ID vaccination route."

    "Since it is likely that a ricin vaccine would be used in an emergency setting or by the military, the ease of ID vaccination with jet injectors or similar devices with lower doses of vaccine is rather important," stated Robert N. Brey, PhD, Chief Scientific Officer of Soligenix.  "It should also be noted that ID vaccination was highly effective at protecting the lungs of the mice from ricin aerosols, a likely route of delivery in the setting of bioterrorism."

    The article, entitled "Intradermal administration of RiVax™ protects mice from mucosal and systemic ricin intoxication," was authored by Drs. Marconescu, Smallshaw, Pop, Ruback, and Vitetta at UT Southwestern. The research was funded directly by an NIH grant to UT Southwestern
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    SOURCE Soligenix, Inc.
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