Navigation Links
Soligenix Announces Preliminary Results of its Phase 2 Clinical Trial of orBec® in the Prevention of Acute GVHD
Date:10/25/2010

ducted primarily at the Fred Hutchinson Cancer Research Center in Seattle, WA and was supported, in large part, by a National Institutes of Health (NIH) grant.  The impetus for this NIH-funded prevention study came from two double-blind, randomized, placebo-controlled trials showing that orBec® was effective and safe as a treatment for acute gastrointestinal (GI) GVHD.  

Paul J. Martin, MD, Principal Investigator for the Phase 2 study and a Member, Fred Hutchinson Cancer Research Center stated, "Trials with orBec® have shown a consistent and positive clinical response in the treatment of acute GI GVHD.  We therefore designed a trial to determine whether orBec® could be used to prevent GVHD. Preliminary analysis indicates that administration of orBec®  starting before transplantation did not provide a statistically significant clinical advantage in preventing acute GVHD in this study, possibly because of confounding factors associated with the chemotherapy or radiation.  Preventive administration of orBec® to reduce the incidence or severity of GVHD warrants further investigation, for example, by starting orBec® dosing after transplantation, closer to the initial inflammatory insult of acute GVHD.  We are continuing to analyze the data in order to gain a better understanding of potential preventive treatment effects in this patient population and to determine the best approach for subsequent study."   

Dr. Martin continued, "In my mind, the results from this prevention study have no clinical implication regarding the likelihood of success in the ongoing Phase 3 study of orBec® for the treatment of acute GI GVHD."

"This Phase 2 clinical trial was truly proof-of-concept and the first of its kind. It was an aggressive approach to determining if a topically-a
'/>"/>

SOURCE Soligenix, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Soligenix Announces Publication of Positive Stability Results with RiVax(TM), its Vaccine Against Ricin Toxin
2. Soligenix Announces Publication of Positive Pre-Clinical Results with RiVax(TM), Its Vaccine Against Ricin Toxin
3. Soligenix Announces Initiation of a Phase 1/2 Clinical Trial of SGX201 for the Prevention of Acute Radiation Enteritis
4. Soligenix Forms Consortium to Develop Thermostable Technology to Advance RiVax(TM) and Other Rapidly Acting Vaccines
5. Soligenix Announces Issuance of Hong Kong Patent for its LPM(TM) Oral Drug Delivery Technology
6. Soligenix Announces Publication of Positive Data Describing Protection from Mucosal and Systemic Ricin Intoxication by Intradermal RiVax™ Administration
7. Soligenix to Present at the OneMedForum Conference on Wednesday, June 30 at 2PM EDT
8. Soligenix Announces Award of $1.2 Million FDA Orphan Products Development Grant
9. Soligenix to Present at the Rodman & Renshaw Healthcare Conference on September 15, 2010 at 10AM EDT
10. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
11. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... mayo de 2015 Dipexium Pharmaceuticals, ... farmacéutica de fase tardía centrada en el ... 0.8%), y colaboradores de investigación clínica, han ... el diseño innovador de los ensayos pivotales ... evalúan Locilex®, su nuevo péptido de antibiótico ...
(Date:5/22/2015)... , May 22, 2015  Effective staffing ... pharmaceutical brand recognition and success. ... a study to provide pharmaceutical and biotech marketing ... (FTEs and budget) that are being channeled into ... biotech marketing managers can utilize this report to ...
(Date:5/22/2015)... May 22, 2015 The Assistance Fund announces ... program provides financial assistance for copay to individuals diagnosed ... announce the addition of the Melanoma Copay Assistance Program ... McGreevy , executive director. "With each additional program we ... a world where no one is denied access to ...
Breaking Medicine Technology:Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 2Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 3Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 4Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 5Dipexium anuncia presentación en el séptimo Simposio Internacional sobre el Pie Diabético 6Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2The Assistance Fund Adds Melanoma Assistance Program 2
... Pharmaceuticals Inc . (Nasdaq: CPIX) is pleased to ... Directors. A healthcare veteran with more than 30 ... President and Chief Executive Officer of Nashville-based Psychiatric Solutions, Inc. ... $2 billion behavioral healthcare system before the company,s sale to ...
... Jan. 6, 2011 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (Nasdaq: ... China, announced today its preliminary unaudited sales range for the ... conference call to discuss these preliminary sales will be held ... (January 6, 2011 at 9:00 pm China Standard Time). The ...
Cached Medicine Technology:Cumberland Pharmaceuticals Announces Joey Jacobs Has Joined Its Board of Directors 2Sinovac Provides Preliminary Unaudited Fourth Quarter 2010 Sales Range 2Sinovac Provides Preliminary Unaudited Fourth Quarter 2010 Sales Range 3
(Date:5/24/2015)... May 24, 2015 Indiana Fiber Network, ... announces Midwest Telecom of America, Inc. (MTA) has selected ... to Cory Childs, IFN Enterprise Sales Manager, fiber route ... “IFN’s fiber transport provides MTA with the diverse ... their Tier 1 Internet and voice carriers located at ...
(Date:5/23/2015)... 23, 2015 On Saturday, May 23, 2015, ... playground for Branches Florida City exactly five years to the ... in 2010. , A large fire tore through the Branches ... 23, 2010 in the middle of the night as neighbors, ... later declared arson even though it is suspected that the ...
(Date:5/23/2015)... 2015 On Wednesday, May 20, 2015, ... has been the target of a sophisticated cyberattack,” and ... company’s ongoing Information Technology (IT) security efforts in the ... The most notable attack on health insurers was reported ... nation’s second largest health insurer, revealed that they had ...
(Date:5/23/2015)... May 23, 2015 Javon Bea ... the Sports Medicine and Rehabilitation Center, 557 N. Washington ... Mondays, June 1-July 20, 5:30-6:30 pm. , The 8-week ... and Laurie Finke, RN, BSN, who will offer training ... on nutrition, running mechanics and show selection and weekly ...
(Date:5/22/2015)... 22, 2015 Pioneer Millworks, the largest ... forefront of designing with reclaimed wood, introducing their latest ... Angeles, California. Their newest offerings, Vat 35, Reclaimed ... and color to America's largest design event. , “Designers, ... each show, anxious to see and feel the variety ...
Breaking Medicine News(10 mins):Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Five Years After Fire, Branches Rebuilds Playground 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 4Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 2Health News:Pioneer Millworks to Reveal New Design Trends with Reclaimed Wood at Dwell on Design in LA 3
... PITTSBURGH, Aug. 12 In an effort to help individuals ... has introduced a new Web tool that allows its members ... at different medical facilities before scheduling their operation. , ... with additional information to help them research hospital and other ...
... , , , ... CSC (NYSE: CSC ) the top performer in enterprise ... an independent monitor of vendor performance in healthcare technology. , ... The report, Staying on Target with ERP Implementations: A Report ...
... , , CARROLLTON, ... A-Claim(TM) medical payment solution helps physicians and hospitals accurately determine ... announced its endorsement of the Medical Group Management Association,s (MGMA) ... Project SwipeIT ( www.SwipeIT.org ) initiative in January to encourage ...
... , PRINCETON, N.J. and LOS ANGELES, Aug. 12 ... care, and the Entertainment Industry Foundation (EIF), a leading charitable organization ... as a means to help prevent diabetes. As an ambassador ... a public service announcement (PSA) to educate families about the prevalence ...
... Elsevier, the world-leading publisher of scientific, technical and ... of this year,s International Brain Mapping and Intraoperative Surgical ... at the 6th Annual World Congress for Brain Mapping ... Medical School, Boston, USA, organized by Elsevier and the ...
... Montefiore,s Institute for Reproductive Medicine & Health Only ... Metro Area to Offer This Breakthrough Procedure , , ... start a family in the future now have a new option. Montefiore,s ... New York metropolitan area and one of approximately 25 sites across the ...
Cached Medicine News:Health News:Highmark's Online Tool Helps Consumers Compare Costs for Elective Surgeries 2Health News:Healthcare Providers Rank CSC First in ERP Implementations 2Health News:Healthcare Providers Rank CSC First in ERP Implementations 3Health News:Preferred Health Technology Announces Support for MGMA's Project SwipeIT 2Health News:Dwayne Johnson, Novo Nordisk and the Entertainment Industry Foundation Educate Families about Healthy Living and Diabetes 2Health News:Dwayne Johnson, Novo Nordisk and the Entertainment Industry Foundation Educate Families about Healthy Living and Diabetes 3Health News:Bob Woodruff, SGM (ret) Colin Rich and Senator John Kerry honored at IBMISPS Annual Awards 2Health News:Bob Woodruff, SGM (ret) Colin Rich and Senator John Kerry honored at IBMISPS Annual Awards 3Health News:New Fertility Treatment Option Now Available for Cancer Patients 2Health News:New Fertility Treatment Option Now Available for Cancer Patients 3Health News:New Fertility Treatment Option Now Available for Cancer Patients 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: