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Soligenix Announces Further Progress with ThermoVax™ for Long-Term Vaccine ThermoStability
Date:4/25/2012

PRINCETON, N.J., April 25, 2012 /PRNewswire/ -- Soligenix, Inc. (OTCBB: SNGX) (Soligenix or the Company), a development stage biopharmaceutical company, announced today further progress in the development of ThermoVax™, its proprietary vaccine thermostabilization technology.  Progress has been based on additional characterization of the stability of prototype vaccines that have been kept at elevated temperatures in excess of three months. These studies are being conducted as part of a continuing program to evaluate the effectiveness of vaccines designed to withstand extremes of temperature and other environmental stress conditions.  The research and development of ThermoVax™ is being supported by a $9.4 million National Institute of Allergy and Infectious Disease (NIAID) grant to Soligenix for biodefense indications against ricin toxin and anthrax exposure.

Prior results have indicated that the Company's aluminum-adjuvanted ricin toxin vaccine, known as RiVax™, retained effectiveness and potency while stored at 40 degrees Celsius for one month when combined with the ThermoVax™ technology.  Confirmatory results have now extended these initial observations to more than three months when the vaccine is kept at 40 degrees Celsius.  In contrast, liquid RiVax™ vaccine when stored at 40 degrees Celsius rapidly degraded and no longer maintained its effectiveness. This is due to the fact that the ricin A chain is normally extremely labile and sensitive to temperature, and rapidly loses its ability to induce neutralizing antibodies when exposed to temperatures higher than 8 degrees Celsius.  ThermoVax™ is able to produce stable and potent vaccine formulations by combining precise lyophilzation technology with conventional aluminum adjuvants, secondary adjuvants (for rapid onset of immunity), and protein subunits.  

The removal of water from pharmaceutical preparations by lyophilization is
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