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Slo-Niacin(R) Offers More Than 20 Years of Heart Health Support
Date:3/2/2010

MAPLE GROVE, Minn., March 2 /PRNewswire/ -- Slo-Niacin®, a nonprescription dietary niacin supplement, features nicotinic acid - the most effective substance available for increasing high-density lipoprotein (HDL), "good cholesterol."(1) First used in the 1950s, nicotinic acid is the oldest of today's most commonly used agents used for lowering cholesterol.(2) Slo-Niacin® has been on the market for more than 20 years, selling nearly 10 million bottles to date.

"Slo-Niacin® contains niacin, which has been clinically proven to be an extremely effect agent for raising HDL and lowering LDL," states Mark Evenstad, president of Upsher-Smith Laboratories, Inc. "It has been studied for more than 20 years as a monotherapy for cholesterol management and as an adjunct to prescription cholesterol-lowering agents."

Niacin is a naturally occurring type of B vitamin that aids in the function of the digestive system, skin, nerves and heart health.(3) It's used to refer to both nicotinic acid and a closely related molecule, nicotinamide, but only nicotinic acid has been shown to have beneficial effects on cholesterol.(2)

When used under the care and monitoring of a healthcare provider, Slo-Niacin® has been clinically proven to raise HDL and lower low-density lipoprotein (LDL), or "bad cholesterol," total cholesterol, and triglycerides on its own and in combination with other cholesterol-lowering agents, such as statins.(4-7) Persons already taking cholesterol lowering drugs should contact a healthcare provider before taking niacin because of possible side effects.(8)

A healthy total cholesterol number should be less than 200. An estimated 102 million adults in the U.S. have total cholesterol levels that are considered borderline-high risk (200-230 mg/dL). Of this group, almost 36 million have total cholesterol levels that are considered high risk (>240 mg/dL).(9) The National Cholesterol Education Program recommends that all adults have their cholesterol checked once every five years.(10)

Dietary supplement niacin is sold in three forms: immediate-release, controlled-release and "flush-free." Immediate-release niacin can be inconvenient because it requires relatively small doses to be taken several times a day and the side effects, such as flushing, can be problematic. Controlled-release niacin, such as Slo-Niacin®, is less likely to cause flushing. Inositol hexaniacinate and nicotinamide, both referred to as "flush-free" niacin, prevent flushing but have not been shown to have any effect on cholesterol levels. Only nicotinic acid has been shown to have beneficial effects on cholesterol.(2)

Slo-Niacin® Tablets utilize a patented polygel® controlled-release delivery system, not available in other dietary supplement niacin products, that assures the gradual and measured release of niacin. It is designed to reduce the incidence of flushing commonly associated with immediate-release niacin use.(8)

Slo-Niacin® is economical and often costs less than an insurance co-payment. At approximately $16 per month for 100 500-mg tablets, Slo-Niacin® helps heart health without hurting your wallet.(11) Patients should talk with their healthcare provider about how Slo-Niacin® may help them.

Three dosage strengths (250 mg, 500 mg, and 750 mg) of Slo-Niacin® Tablets are available to meet the specific goals you set with your healthcare provider. But before using more than 500 mg daily, consult your healthcare provider, because niacin can cause side effects when used in high doses.(8) Proper monitoring by a healthcare provider can help manage side effects.

Slo-Niacin® Tablets are manufactured by Upsher-Smith Laboratories, Inc., a trusted manufacturer of high quality prescription and dietary supplement products, and are conveniently available at pharmacies and other retailers nationwide. For more information, contact a healthcare professional, call 1-800-654-2299 or visit www.Slo-Niacin.com for more information, coupons and a store locator.

About Upsher-Smith Laboratories, Inc.

Upsher-Smith Laboratories, Inc. is a rapidly growing pharmaceutical company that manufactures and markets both prescription and consumer products. Privately held since 1919, the company strives to recognize the unmet healthcare needs of our customers. Over the last 20 years that Upsher-Smith has been manufacturing Slo-Niacin®, more than 9.3 million bottles have been sold. Upsher-Smith prides itself in providing safe, effective, and economical therapies to the ever-challenged healthcare environment. For additional information about Upsher-Smith, visit www.upsher-smith.com.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Important Safety Information

Read the information leaflet provided with each bottle of Slo-Niacin® Tablets.

Do not use Slo-Niacin® Tablets if you have a known sensitivity or allergy to niacin.  Do not take niacin unless under your healthcare provider's supervision if you have heart disease (particularly, recurrent chest pain or recent heart attack), gallbladder disease, gout, arterial bleeding, glaucoma, diabetes, impaired liver function, stomach ulcers, or are pregnant or lactating.  Before taking more than 500 mg/day, call your healthcare provider.  If you are taking high blood pressure or cholesterol-lowering drugs, call your healthcare provider before taking niacin due to possible interactions.  Case reports of unexplained muscle-related complaints, including discomfort, weakness, or tenderness, have been documented with HMG-CoA Reductase Inhibitors in combination with niacin.  Increased uric acid, glucose, and abnormal liver function tests have been reported in persons taking 500 mg/day or more.  Discontinue use and call your healthcare provider immediately if you experience persistent flu-like symptoms (nausea, vomiting, not feeling well), loss of appetite, decreased and dark-colored urine, muscle discomfort or weakness, irregular heartbeat or vision problems.  Niacin may cause temporary flushing, itching and tingling, feelings of warmth and headache, particularly when beginning, increasing dosage or changing brands.  This safety information is not all-inclusive.  For more information, contact your healthcare provider, call 1-800-654-2299, or visit www.slo-niacin.com.

References:

(1) Mayo Clinic. http://www.mayoclinic.com/health/niacin/cl00036. April 13, 2009.

(2) Harvard Health Letter. "Niacin into the void: Failure of HDL cholesterol drug may be this B vitamin's big chance." April 2007.

(3) MedlinePlus. Niacin. http://www.nlm.nih.gov/medlineplus/ency/article/002409.htm. Accessed December 17, 2009.

(4) Lavie CJ, Mailander L, Milani. "Marked benefit with sustained-release niacin therapy in patients with 'isolated' very low levels of high-density lipoprotein cholesterol and coronary artery disease." Am J Cardiol. 1992;69:1083-1085.

(5) Squires RW, Allison TG, Gau GT, et al. "Low-Dose, Time-Release Nicotinic Acid: Effects in Selected Patients With Low Concentrations of High-Density Lipoprotein Cholesterol." Mayo Clin Proc. 67:855-860, 1992.

(6) Gray DR, Morgan T, Chretien SD, Kashyap ML. "Efficacy and Safety of Controlled-Release Niacin in Dyslipoproteinemic Veterans." Ann Intern Med. 1994;121:252-258.

(7) Knopp RF, Retzlaff BM, Fish B et al. "The SLIM study: Slo-Niacin® and Atorvastatin Treatment of Lipoproteins and Inflammatory Markers in Combined Hyperlipidemia." Journal of Clinical Lipidology, Volume 3, Issue 3, Pages 167-178.

(8) Slo-Niacin product information. http://www.slo-niacin.com/images/pi.pdf. Upsher-Smith Laboratories, 2003.

(9) American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=4506. April 13, 2009.

(10) Centers for Disease Control and Prevention. http://www.cdc.gov/cholesterol/facts.htm. April 13, 2009.

(11) Drugstore.com website. http://www.drugstore.com. Accessed February 10, 2010.

SOURCE Upsher-Smith Laboratories, Inc.

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