Navigation Links
Skin Flaps Deliver Cancer-fighting Therapy, ASPS Study Reveals
Date:5/8/2008

Treatment Provides "Blueprint" to Produce Therapeutic Proteins at Tumor Site

ARLINGTON HEIGHTS, Ill., May 8 /PRNewswire-USNewswire/ -- Using gene therapy, plastic surgeons have delivered cancer fighting proteins through skin flaps placed on cancerous tumors on rats with a 79 percent reduction in tumor volume, according to a study in the May issue of Plastic and Reconstructive Surgery(R), the official medical journal of the American Society of Plastic Surgeons (ASPS). This new delivery technique, which has yet to be tested in humans, did not cause toxicity in the body of rats; however, administering the same anti-tumor agent intravenously in humans has previously been shown to cause liver damage.

"This new technique may allow us to reprogram skin flaps, using gene therapy, to provide a blueprint for anti-tumor agents like Interleukin-12 to be produced in the tumor to kill cancer, while avoiding adverse side effects," said Geoffrey Gurtner, MD, ASPS Member and study senior author. "In this study we took skin flaps in animal models and delivered IL-12 directly to the tumor area with tremendous success. Since skin flaps are used thousands of times each year in cancer patients, this may potentially open up an entirely new area in plastic surgery and bring the specialty, once again, to the center of medicine."

Gene therapy has been heralded as a new tool to restrain or prevent tumor growth and recurrence in humans, but its use has been limited because of serious side effects and the difficulty in concentrating anti-tumor agents at the site of the cancer.

In the study, skin flaps (a mass of healthy tissue) taken from rats were injected with the gene for IL-12 into the flaps' blood supply. The flaps were then placed onto cancerous tumors on the rats.

The study found a 79 percent reduction in tumor volume for animals treated with IL-12 compared to control animals. The treatment allowed individual cells within the flap to be
'/>"/>

SOURCE American Society of Plastic Surgeons
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. The Female Health Company Receives USAID DELIVER PROJECT Order for 5 Million Units
2. CellCyte Genetics Corp. Enters Collaborative Research Agreement With Cleveland Clinic Foundation to Qualify Stem Cell Delivery in Damaged Heart Tissue
3. New Analysis of Study Data Shows That Asacol(R) (Mesalamine) Delivers Rapid Symptom Relief for Ulcerative Colitis Patients
4. Intradigm Study Shows Ability of siRNAs Systemically Delivered With TargeTran(TM) System to Suppress Tumor-Induced Angiogenesis in Mice
5. Researchers Train the Immune System to Deliver Virus That Destroys Cancer in Lab Models
6. Dr. Rajeev Venkayya Joins Gates Foundation as Director of Global Health Delivery
7. Study Shows Intradigms RNAi Nanoplex Technology To Be Effective Systemic siRNA Delivery Platform for the Treatment of Various Cancer Models
8. Micromet Shows Feasibility of Subcutaneous Delivery of BiTE Antibody in Preclinical Primate Study
9. Halozyme Therapeutics Presents Pre-Clinical Studies of Systemic Delivery of Pegylated rHuPH20 Enyzme in Prostate Cancer Models at American Association for Cancer Research Conference
10. In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy
11. PARIs eFlow Delivers Alnylam RNAi Therapeutic in Phase II Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... DUBLIN, Ohio and MELVILLE, N.Y. ... (NYSE: CAH ), one of the world,s ... (NASDAQ: HSIC ), the world,s largest provider ... animal health and medical practitioners, today announced that the ... provide one of the most comprehensive service and product ...
(Date:11/21/2014)... Nov. 20, 2014  RedRick Technologies, a provider ... reading room environment guidance, has helped the new ... reading room, which may also serve as a ... Medicine. "In line with the ... of Radiology,s Imaging 3.0 ™ initiative, the ...
(Date:11/21/2014)... 20, 2014 Depomed, Inc. (NASDAQ: DEPO ) ... 26 th Annual Healthcare Conference in New York ... conference is scheduled for 8:00 am EST (5:00 am PST) on ... webcast can be accessed via the Investor Relations page of the ... will be archived for 30 days on the company,s website. ...
Breaking Medicine Technology:Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 2Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 3Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 4Cardinal Health And Henry Schein Enter Into Long-Term Strategic Agreement To Serve Physician Offices 5RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 2RedRick Technologies Helps Penn Radiology Implement New Radiology Reading Room Concepts 3Depomed To Present At Piper Jaffray 26th Annual Healthcare Conference 2
... 2011 Varian Medical Systems (NYSE: VAR ... to support the company,s ongoing growth and safety initiatives. ... for the company, has been named Chief Operating Officer ... promotion, and sale of all Varian products and services ...
... PARSIPPANY, N.J., Oct. 3, 2011 To help frustrated ... to their chronic nasal congestion and trouble with sleep, ... Sperling,s BestPlaces to identify the 20 Most Congested Cities ... top 20 metropolitan areas where residents are most challenged ...
Cached Medicine Technology:Varian Medical Systems Announces New Management Positions 2Varian Medical Systems Announces New Management Positions 3Varian Medical Systems Announces New Management Positions 420 Most Congested Cities in U.S. Unveiled 220 Most Congested Cities in U.S. Unveiled 320 Most Congested Cities in U.S. Unveiled 4
(Date:11/23/2014)... Locks-Magnetic.com, a notable magnetic locks maker, has ... new products are available at low rates up to ... of the new emergency doors. The emergency door adopts ... choose from several colors. All of the products are ... release is not as easy as many people think. ...
(Date:11/23/2014)... AngelWeddingDress.com has recently updated its ... beach wedding dresses. “If you are looking for gorgeous ... soon as possible. Here you can enjoy 70% off ... , Holding a big marriage ceremony is the most ... beach wedding dress is uppermost priority. Ophelia, one of ...
(Date:11/23/2014)... November 23, 2014 Wright & Schulte ... of Ohio and West Virginia residents who allege that ... health disorders due to drinking C8 contaminated water ... West Virginia. According to the C8 complaints, the plaintiffs ... worked or lived in at least one of the ...
(Date:11/22/2014)... (PRWEB) November 23, 2014 Cancer researchers ... a connection between intercellular communication tunnels and the growth ... the full story on the Surviving Mesothelioma website. ... and the University of Minnesota have just released their ... information and materials between cells. They found that ...
(Date:11/22/2014)... 2014 BambooFlooringChina.com is a famous ... proudly released its new collection of bamboo mats ; ... to 29% off. , According to the sales ... grass, making it a highly renewable resource. Their bamboo mats ... mixing color which comes from natural bamboo with caramel bamboo ...
Breaking Medicine News(10 mins):Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 2Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 3Health News:40 C8 Lawsuit Claims Filed By Wright & Schulte LLC Alleged Serious Illness Due To C8 Contaminated Water In Ohio And West Virginia 4Health News:Study Links Cellular ‘Tunnels’ to Mesothelioma Proliferation, According to Surviving Mesothelioma 2Health News:Trendy Bamboo Mats Online Now By BambooFlooringChina.com 2
... One in eight parents reported that his or ... laboratory testing and/or appointments with specialists during the ... payment, according to a study, presented Sunday, Oct. 3, ... and Exhibition in San Francisco. For the ...
... , FRIDAY, Oct. 1 (HealthDay News) -- Doctors who take ... lifestyle habits to their patients than doctors who gobble down ... hit the gym, according to new research. Additionally, the ... they,d been well-trained to counsel their patients on lifestyle changes ...
... identify obscure cartoon characters than the native plants and animals ... connection to the natural world can have a profound impact ... author who coined the phrase, "nature-deficit disorder," will address this ... Pediatrics (AAP) National Conference & Exhibition Saturday, Oct. 2. His ...
... department at a mid-sized hospital were able to increase ... for measuring general technologist productivity, according to a study ... American College of Radiology ( www.jacr.org ). ... priorities that may be difficult to achieve simultaneously," said ...
... Johns Hopkins scientists have discovered a way to turn off ... mice, a discovery that could have implications for the millions ... peanuts and milk. The findings, published online in the ... could be trained to tolerate food allergies that lead to ...
... review article published in the October issue of ... Clinic physicians differentiate the ethical and legal permissibility ... comfort measures, specifically palliative sedation, from that of ... that palliative sedation has an important place on ...
Cached Medicine News:Health News:1 in 8 parents forgoes pediatrician-recommended care 2Health News:Doctors' Health, Well-Being Affect Patient Counseling 2Health News:Doctors' Health, Well-Being Affect Patient Counseling 3Health News:Johns Hopkins researchers turn off severe food allergies in mice 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: