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Six Presentations on Tocagen's Toca 511 to be Given at the Society of Neuro-Oncology Annual Meeting
Date:11/22/2013

SAN DIEGO, Nov. 22, 2013 /PRNewswire/ -- Tocagen Inc. today announced that six presentations on Toca 511 will be given at the Society of Neuro-Oncology (SNO) Annual Meeting, including interim clinical data from two ongoing Phase I investigational studies, which show that, to date, Toca 511 administration followed by oral courses of Toca FC is safe and well tolerated, and demonstrated antitumor activity in some patients with high grade glioma (HGG). HGG includes glioblastoma multiforme (GBM), the most common and aggressive form of primary brain cancer. Toca 511 is a retroviral replicating vector that carries a gene for an enzyme that converts orally delivered Toca FC (extended-release 5-FC) into 5-FU, a potent anti-cancer agent.

The data will be presented at the 4th Quadrennial Meeting of the World Federation of Neuro-Oncology held in conjunction with the 18th Annual Meeting of the Society for Neuro-Oncology in San Francisco. Timothy Cloughesy, M.D., director of the Neuro-Oncology Program at the University California, Los Angeles Jonsson Cancer Center and a principal investigator for the Toca 511 resection study, will make an oral presentation titled "Evidence supporting mechanism of action and drug activity in Phase I trial of patients with recurrent high grade glioma administered Toca 511 at the time of surgical resection followed by Toca FC." This presentation will be given on Sunday, Nov. 24, during the Biologic/Immunologic Therapies session from 10:20 a.m. to 12 p.m. PST.

Data from additional studies of Toca 511 will be presented at the conference in the following poster presentations:

  • "A phase I trial of a retroviral replicating vector (Toca 511) in patients with recurrent high grade glioma demonstrates importance of real-
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SOURCE Tocagen Inc.
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