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Sirion Therapeutics Announces Positive Phase III Results for Difluprednate
Date:10/25/2007

on to ophthalmologists and patients."

About Post-Operative Inflammation

There are more than 3.5 million ophthalmic surgeries performed each year in the United States. Post-operative inflammation is a common occurrence following these procedures. While it tends to be self-resolving, some cases can lead to serious sequelae. If left untreated, inflammation following ocular surgery can interfere with the patient's visual rehabilitation or lead to further complications, such as acute pain and discomfort, chronic cystoid macular edema, posterior capsule fibrosis, keratopathy, fibrin reaction, or chronic uveitis. As there is no way to predict which patients might develop inflammatory complications, doctors often prescribe steroids and/or NSAID drops. Most often, post-operative inflammation lasts a relatively short time, though severe forms of inflammation can persist for a longer period of time.

About Difluprednate (ST-601)

Difluprednate is a potent ophthalmic steroid emulsion that has the potential to treat patients suffering from ocular inflammatory disease. Difluprednate's unique formulation permits rapid penetration of the cornea, which promotes quick resolution of anterior chamber cells and flare. A Phase 3 program evaluating difluprednate in patients with post-surgical inflammation was completed in September of 2007, showing difluprednate's potential to rapidly eradicate ocular inflammation versus placebo while maintaining an acceptable safety profile. In addition to post-surgical inflammation, difluprednate is being evaluated in a Phase 3 program as a treatment for patients with uveitis.

About Sirion Therapeutics, Inc.

Sirion Therapeutics is a privately held biopharmaceutical company pursuing the discovery, development and commercialization of products addressing unmet medical needs in the protection and preservation of eyesight. Sirion's pipeline includes four late-stage opportunities: ganciclovir, a topical antiviral for herpeti
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SOURCE Sirion Therapeutics, Inc.
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