Navigation Links
Single Dose of Proprietary Adult Stem Cells Regenerates Damaged Pancreas and Reduces Blood Glucose Levels in Diabetes
Date:12/17/2009

Type 2 diabetes accounts for 90-95 per cent of the 230 million diabetics in the western world, and its prevalence is increasing at an alarming rate. Complications include heart disease, chronic kidney failure, blindness, nerve damage and lower extremity amputations. Injections of insulin are used only as a last resort in Type 2 diabetics because of the risk of lowering glucose levels too greatly and too rapidly (hypoglycemia). Newer treatment modalities for Type 2 diabetes aim to enhance the ability of pancreatic beta cells to produce more insulin in an effort to better control blood glucose.

In the collaborative study, diabetes was induced by partial chemical destruction of the pancreas in 35 mice that were then randomised to receive either a single injection into the bloodstream of human MPCs or control. Three weeks later, MPC-treated diabetics had two-fold greater numbers of pancreatic islets than diabetic controls (p=0.0012), and a ratio of insulin-producing beta cells to glucagon-producing alpha cells which was 29% higher than in diabetic controls (p=0.005). MPC-treated diabetics demonstrated a 35% maximal reduction in blood glucose levels (p=0.012) and a 34% increase in blood insulin levels (p=0.04) compared with diabetic controls over the three weeks of follow-up. No subjects had reduction in glucose levels below normal, indicating that MPCs may have a safer profile than insulin injections with respect to risk of hypoglycemia.

"These results suggest that the MPCs enhanced endogenous pancreatic beta cell regeneration, resulting in safe and sustained augmentation of insulin secretion and reduction in blood glucose levels," Professor Horowitz added.

Mesoblast Executive Director, Professor Silviu Itescu, said: "The Company will move quickly towards the clinic to target what is termed the western world's largest healthcare epidemic.

"We believe there is clear proof of principle to use our patented cells for diabetes
'/>"/>

SOURCE Mesoblast
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. MAQUET Cardiovascular Awarded Three-Year Single Source Contract From Novation for VASOVIEW Endoscopic Vessel Harvesting Devices
2. Reproductive Partners Announces Elective Single Embryo Transfer (eSET) Encouragement Program
3. American Regent Expands Voluntary Recall to Include All Lots of Ketorolac Tromethamine Injection, USP 15 mg/mL; 1mL Single Dose Vials
4. Sagent Pharmaceuticals Announces Launch of Adenosine Injection, USP, in 6 mg per 2 mL Single-Dose Vials
5. FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent
6. Single Port Surgeries Now Performed at University Medical Center at Princeton
7. Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401s Activity in the Treatment of Advanced Metastatic Renal Cell Cancer
8. Scientists Discover Why Teeth Form in a Single Row
9. New Research Suggests Platelet Stickiness May be the Single Most Important Risk Factor in Patients Treated with Coronary Stents - Findings May be Applicable to Anyone with Vascular Disease
10. Huntington Hospital Surgeon Performs First Single Port Resection on Colorectal Cancer Patient in CA
11. Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Consolidated Net Profit increased by 43.65 % to Rs. 1848.46 ... India Business grew by 20.87% to Rs. 3,971.59 Mn ... Rest of World (ROW) Business grew by 20.67% to Rs. 2,113.09 ... 977.26 Mn Latin America Business grew by 33.92% to ... the research-led global integrated pharmaceutical company, today announced its results for ...
(Date:7/24/2014)... , July 24, 2014  In any given ... in 25 patients has at least one hospital-acquired infection, ... What,s more, many of these infections prove fatal. And ... an alarming number of patient deaths per year, infection ... conversation. Consequently, a stronger emphasis is ...
(Date:7/24/2014)... /PRNewswire-iReach/ -- Delivery of the Report will take ... Photo - http://photos.prnewswire.com/prnh/20140723/129707 ... survey on Global and Chinese Hemodialysis Machine industry. ... Hemodialysis Machine including its classification, application and manufacturing ... top manufacturers of Hemodialysis Machine listing their product ...
Breaking Medicine Technology:Glenmark's Consolidated Revenue Increases by 20.08% to Rs. 14,869.40 Mn for Q1 FY 14 - 15 2Glenmark's Consolidated Revenue Increases by 20.08% to Rs. 14,869.40 Mn for Q1 FY 14 - 15 3Glenmark's Consolidated Revenue Increases by 20.08% to Rs. 14,869.40 Mn for Q1 FY 14 - 15 4Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 2Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 3Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 2Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 3Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 4Hemodialysis Machine Industry for Global and Chinese Markets Forecast to 2019 5
... , University of Michigan tests show short-term ... raise risk of heart attack , , ANN ... exercise, a healthy diet and not smoking can help reduce high blood ... the very air we breathe can be an invisible catalyst to heart ...
... , , ... MTA: CTIC) announced today that the U.S. Food and Drug ... Fee Act (PDUFA) action date of April 23, 2010 under ... as potential treatment for relapsed or refractory aggressive non-Hodgkin,s lymphoma ...
Cached Medicine Technology:Inhaling a Heart Attack: How Air Pollution Can Cause Heart Disease 2Inhaling a Heart Attack: How Air Pollution Can Cause Heart Disease 3FDA Sets Action Date of April 23, 2010 for Review of Pixantrone NDA 2FDA Sets Action Date of April 23, 2010 for Review of Pixantrone NDA 3
(Date:7/25/2014)... and desires in initial romantic encounters determine the fate ... those initial "sparks" necessary to fuel sexual desire and ... a desirable trait for both men and women on ... the other person? Do men perceive responsive women as ... women,s perceptions of men? A study published in ...
(Date:7/25/2014)... San Mateo, CA (PRWEB) July 25, 2014 ... in an upcoming episode of Innovations with Ed Begley ... Dates and show times TBA. , For more than ... and the Bay Area community through its residential alcohol ... Innovations will educate on Project Ninety's humble idea and ...
(Date:7/25/2014)... July 25, 2014 Home Care Assistance ... provider of non-medical, in-home senior care, is weighing in ... be supporting senior-led projects in Alberta through their New ... for Seniors Program is a federal grants and contributions ... who make a difference in the lives of others ...
(Date:7/25/2014)... Ca (PRWEB) July 25, 2014 The ... with their Anniversary Futon Sale. The Futon Shop has been ... pop shop, which has grown from a few handmade futon ... 33 different kinds of futon mattresses. , The Futon ... the beginning and the desire to sleep on natural fibers ...
(Date:7/25/2014)... ZeptoMetrix™ Corporation (ZMC), an industry leader ... and services for infectious disease diagnostic development, is ... Multimarker Controls - MDZ001 . , An ... marked, unassayed external run control intended for use ... Multimarker Controls - MDZ001 has been specifically designed ...
Breaking Medicine News(10 mins):Health News:Why do men prefer nice women? 2Health News:Why do men prefer nice women? 3Health News:Project Ninety to be Featured on Innovations with Ed Begley, Jr. 2Health News:Project Ninety to be Featured on Innovations with Ed Begley, Jr. 3Health News:Home Care Assistance – Halton/Peel Region Weighs in on Alberta Communities Receiving Funding to Support Seniors and Senior Caregivers 2Health News:Home Care Assistance – Halton/Peel Region Weighs in on Alberta Communities Receiving Funding to Support Seniors and Senior Caregivers 3Health News:Organic Mattress Manufacturer Celebrates 38 Years Of Being In Business 2Health News:Organic Mattress Manufacturer Celebrates 38 Years Of Being In Business 3Health News:ZeptoMetrix™ Corporation (ZMC) Releases FDA Class 1 Exempt, IVD and CE Labeled NATtrol™ RP Multimarker Controls 2
... protecting children from flu if they included both strains of ... has found. "Adding a second influenza B virus strain ... guesswork out of strain selection and help improve the vaccine,s ... and director of the Center for Vaccine Development at Saint ...
... ... Wigix Inc.’s subsidiary, ddku.com, affording it an end to end marketing platform in China. ... Oakland, CA ... has acquired a Shanghai-based business process outsourcing company, Mag2U, to enhance DDKU’s growing internet ...
... testing, experts say , TUESDAY, April 6 (HealthDay News) -- ... have a genetic mutation that boosts their risk for the ... breast than are women who don,t have the genetic mutations, ... these women, who carry a mutation in the BRCA1 and ...
... Today, the Interactive Autism Network (IAN), www.ianproject.org, the ... of the Grandparents of Children with Autism Spectrum ... who participated were the first to raise concerns ... 2007, the IAN Project has helped to accelerate ...
... Indianapolis, 6 April, 2010 The global nursing shortage is ... schools and to a phenomenon known as nurse migration, where ... response, the International Council of Nurses (ICN) and the Honor ... The Elsevier Foundation, will conduct the Global Summit on Nurse ...
... April 2010 - Attention-deficit/hyperactivity disorder (ADHD) is one of ... adolescents. Children with ADHD are excessively restless, impulsive, and ... Problems inhibiting behavior are a common theme for ADHD ... medications, behavioral approaches or a combination of the two. ...
Cached Medicine News:Health News:Building a better flu vaccine: Add second strain of influenza B 2Health News:Wigix Acquires Mag2U, A Leading Business Process Outsourcing Company 2Health News:Wigix Acquires Mag2U, A Leading Business Process Outsourcing Company 3Health News:Gene Mutations Up Risk for Cancer in Opposite Breast 2Health News:Gene Mutations Up Risk for Cancer in Opposite Breast 3Health News:New survey finds grandparents play key role in lives of children with autism 2Health News:New survey finds grandparents play key role in lives of children with autism 3Health News:International summit seeks solutions to global shortage of nursing faculty 2Health News:Synergy between behavioral and pharmacologic interventions for ADHD 2
... Protection Made Easy. The new generation FilterWire ... and ease of use, providing you with ... stenting and angioplasty procedures., ,The FilterWire EZ ... requiring minimal changes to technique. The ...
... large sizes, noise is not a factor ... tabs. For use with mini-crocodile clip lead ... tabs-2.2 x 2.5 cm (.875 x 1 ... Each 100-count package contains 10 individually sealed ...
... images and patient information from all ... in one central system. It simplifies ... cost-effectiveness so that healthcare professionals can ... helping people., ,Many Sources, One Solution ...
... many surgeons turn it down confidently knowing ... the going gets tough. More important are the ... and the technologically advanced fan we build into ... ups and overheating. The result is dependable, extreme ...
Medicine Products: