Navigation Links
Sinai Researchers Find Link Between Exposure to World Trade Center Dust and Prostate Cancer
Date:6/20/2019

World Trade Center (WTC) responders with prostate cancer showed signs that exposure to dust from the World Trade Center site had activated chronic inflammation in their prostates, which may have contributed to their cancer, according to a study by Mount Sinai researchers in Molecular Cancer Research in June.

Inflammation has long been considered an important factor in prostate cancer progression. Researchers looked at the inflammatory and immune systems of World Trade Center responders to help prevent new prostate cancer cases in that group and to understand how other large-scale environmental exposures to multiple carcinogens may develop into cancer.

This is the first study of people who were exposed to the WTC dust and who subsequently developed prostate cancer. This research and further study of the expression of genes and pathways in other patients whose environmental exposures caused inflammation could lead to clinical trials that offer anti-inflammatory or immune-targeted therapies in similar cases.

“World Trade Center responders show an overall increase in cancer incidence, and specifically of certain cancer types such as prostate cancer,” said Emanuela Taioli, MD, PhD, Director of the Institute for Translational Epidemiology at the Icahn School of Medicine at Mount Sinai and Associate Director for Population Science at The Tisch Cancer Institute. “It is important to address the reasons why this is happening in order to prevent new cases in this aging cohort. Our findings represent the first link between exposure to World Trade Center dust and prostate cancer.”

This work pairs data from first responders and from a study of rats exposed to actual dust from Ground Zero. The dust samples, which contain metals and organic compounds such as polycyclic aromatic hydrocarbons and polychlorinated biphenyl, are unique because they are the only existing samples taken on September 11, 2001. All other dust samples were collected after a significant storm on September 14, 2001.

Both the human and rat prostate cancer tissues show an increase in cells that indicate inflammation, specifically immune cells called T helper cells. Studies of the rat tissue and prostate cancer tissue samples taken from responders indicated to the Mount Sinai researchers that chronic inflammation started occurring in the prostate after exposure to the World Trade Center dust, and that inflammation may have contributed to prostate cancer.

“Several years ago, I saw a first responder in his 40s who began having symptoms of prostatitis, a painful condition that involves inflammation of the prostate, soon after exposure to the World Trade Center dust,” said William Oh, MD, Chief of the Division of Hematology and Medical Oncology at the Icahn School of Medicine at Mount Sinai and Deputy Director at The Tisch Cancer Institute. “He ultimately developed a high-grade prostate cancer several years later. It suggested to me that there might be a link between his exposure and cancer, but I knew that I would need to examine it systematically.”

This study was sponsored by grants from the U.S. Centers for Disease Control and Prevention, the National Institute for Occupational Safety and Health, the National Institutes of Health, and the National Institute of Environmental Health Sciences.

About the Mount Sinai Health System

The Mount Sinai Health System is New York City's largest integrated delivery system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai's vision is to produce the safest care, the highest quality, the highest satisfaction, the best access and the best value of any health system in the nation. The Health System includes approximately 7,480 primary and specialty care physicians; 11 joint-venture ambulatory surgery centers; more than 410 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools", aligned with a U.S. News & World Report's "Honor Roll" Hospital, No. 12 in the nation for National Institutes of Health funding, and among the top 10 most innovative research institutions as ranked by the journal Nature in its Nature Innovation Index. This reflects a special level of excellence in education, clinical practice, and research. The Mount Sinai Hospital is ranked No. 18 on U.S. News & World Report's "Honor Roll" of top U.S. hospitals; it is one of the nation's top 20 hospitals in Cardiology/Heart Surgery, Gastroenterology/GI Surgery, Geriatrics, Nephrology, and Neurology/Neurosurgery, and in the top 50 in six other specialties in the 2018-2019 "Best Hospitals" issue. Mount Sinai's Kravis Children's Hospital also is ranked nationally in five out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 11th nationally for Ophthalmology and 44th for Ear, Nose, and Throat. Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West, and South Nassau Communities Hospital are ranked regionally.

For more information, visit http://www.mountsinai.org/, or find Mount Sinai on Facebook, Twitter and YouTube.

Read the full story at https://www.prweb.com/releases/sinai_researchers_find_link_between_exposure_to_world_trade_center_dust_and_prostate_cancer/prweb16393198.htm.


'/>"/>
Source: PRWeb
Copyright©2019 Vocus, Inc.
All rights reserved


Related medicine technology :

1. Berg e la Icahn School of Medicine presso Mount Sinai hanno annunciato una partnership per Ricerca e Sviluppo per la scoperta e lo sviluppo di farmaci
2. Berg und die Icahn School of Medicine at Mount Sinai geben F&E-Partnerschaft zur Erforschung und Entwicklung neuer Arzneimittel bekannt
3. Berg en Icahn School of Medicine van het Mount Sinai kondigen R&D- partnerschap aan voor ontdekking en ontwikkeling van geneesmiddelen
4. Transparency Life Sciences Partners With Oncology Researchers At Icahn School Of Medicine At Mount Sinai To Assess Metformin In Prostate Cancer
5. Synthetic Biologics Enters into License with Cedars-Sinai Medical Center to Develop Novel Anti-infective Approaches for Irritable Bowel Syndrome (IBS), Obesity and Diabetes
6. Hologic Expands its Board of Directors with Appointment of Two Independent Directors and Engages Chairman of Mt. Sinai Radiology Department as Scientific Advisor
7. Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C
8. CURE Urgent Care Expands Partnership with Mount Sinai Health System
9. Regeneron and Icahn School of Medicine at Mount Sinai Announce New Antibody Research Agreement
10. Gradalis Announces Research Alliance with Mount Sinai
11. Mount Sinai Experts Offer Tips on Prevention and Detection for Breast Cancer Awareness Month
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/19/2019)... ... July 19, 2019 , ... The new ... a novel non-invasive transdermal (over-the-skin) technology, which is the leader in the field ... the clinical evidence obtained by Circularity over the past six years. The clinical ...
(Date:7/19/2019)... ... July 19, 2019 , ... Robinson Pharma, Inc., is proud to announce ... was audited by the Safe Quality Food (SQF) Institute using an accredited certification process ... Code for Manufacturing, Edition 8. , The SQF Certification program is trusted by buyers ...
(Date:7/18/2019)... Pa. (PRWEB) , ... July 18, 2019 , ... Fresh ... Bushel and Berry Collection of homegrown edible berry bushes. , These ornamental ... and healthy, delicious fruit to any garden or on the patio in containers, not ...
Breaking Medicine Technology:
(Date:7/18/2019)... DALLAS (PRWEB) , ... July 18, 2019 , ... ... Partners physicians for being nominated 2019 Texas Monthly Super Doctor Rising ... nominate colleagues (excluding themselves) who they would trust for their own medical care. ...
(Date:7/17/2019)... ... 2019 , ... Guruji Mahendra Trivedi, founder of the Trivedi ... affecting humanity at practical and spiritual levels. Guruji Mahendra Trivedi announces a Trivedi ... , Guruji Mahendra Trivedi offers these powerful workshops to deepen the participants’ connection ...
(Date:7/17/2019)... ... July 17, 2019 , ... Dynamic ... in Medicare Advantage, Medicaid, and Marketplace programs is pleased to announce the introduction ... Health Records (EHR) integration at the point of care to providers and ...
(Date:7/17/2019)... ... July 17, 2019 , ... ICD10monitor, an ... ICD-10 coding set, is launching an exclusive educational webcast subscription service featuring 40 ... charge, officials announced this week. , The ICD10monitor webcast portfolio already includes ...
(Date:7/17/2019)... ... July 17, 2019 , ... People considering surrogacy usually have an altruistic ... story differs , but, in addition to creating a family, they have the opportunity ... and more Intended Parents are electing to have a child through the surrogacy process. ...
Breaking Medicine News(10 mins):