Navigation Links
Silicon Nitride Demonstrates Statistical Superior Osteointegration and Anti-infective Biomaterial Properties
Date:9/13/2012

SALT LAKE CITY, Sept. 13, 2012 /PRNewswire/ -- Amedica Corporation, a spinal and reconstructive implant manufacturer, announced today the publication of two peer-reviewed studies conducted at Brown University that demonstrate the superior osteointegration and bacterial-resistant properties of its proprietary Silicon Nitride (Si3N4) biomaterial when compared to poly-ether-ether-ketone (PEEK) or titanium (Ti). In related news, the company also announced the expansion of biomaterial property claims for its line of FDA 510(k) cleared interbody fusion devices.

Spine and orthopedic surgeons have historically relied on allograft bone, metal and plastic implants to aid in spine fusions and joint replacements. Implants have traditionally been comprised of materials that are resistant to host immune mechanisms and systemic antibiotics, creating an environment for significant bacterial growth. As a result, functional implants can become colonized with bacteria, which may reduce fusion rates or cause serious infection. Treating implant-related infection is costly and generally requires extensive repeat surgery that may extend suffering and disability for patients.

The in-vitro data from the journal article titled, "Decreased Bacteria Activity on Si3N4 Surfaces Compared with PEEK or Titanium," which appears in the International Journal of Nanomedicine 2012:7 1-12 reports that Silicon Nitride is far less vulnerable to bacterial colonization (S. epidermidis, S. aureus, P. aeruginosa, E. coli and Enterococcus) than PEEK and titanium. Additionally, because of the positive surface charge, nanostructure and hydrophilic nature of Silicon Nitride, there was also rapid adherence of fibronectin, vitronectin and laminin proteins which can decrease susceptibility to bacteria and increase osteointegration.

An in-vivo study titled, "Anti-infective and Osteointegration Properties of Silicon Nitride, Poly (Ether Ether Ketone), and Titanium Implants," which appears in the July 31 online edition of Acta Biomaterialia (2012), reports that Silicon Nitride demonstrates superior new bone formation and resistance to bacterial infection when compared to PEEK and titanium. Specifically, the amount of regenerated bone associated with Silicon Nitride implants was essentially two- to three- times that of the other two implant materials at three months post-surgery. In as little as 14 days, Silicon Nitride demonstrated significantly greater new bone formation at both the surgical site and the implant interface.  

"Bacterial infection is a serious risk that can lead to non-healing fusions, implant loosening, device failure and, in extreme cases, death," said Dr. Thomas J. Webster, lead investigator, and Chair and Professor of the Department of Chemical Engineering at Northeastern University. "Selectively engineering the biomaterial or surface structure of the implant can decrease bacterial adhesion, lessening the potential for infection. Our study examined the innate biomaterial characteristics of Silicon Nitride, PEEK and titanium, and it was evident that Silicon Nitride holds the greatest potential for decreased risk of bacterial infection."

"Silicon Nitride has been used in spine applications for more than four years with a proven record of safety and effectiveness, and a vast patient population has benefited from this innovative technology," said Eric K. Olson, President and Chief Executive Officer, Amedica. "The increasing body of evidence supporting the benefits of Silicon Nitride for spine and orthopedic surgery indicates that material matters, and that Silicon Nitride interbody fusion devices may achieve faster fusion than PEEK and titanium spacers while reducing the incidents of infection. We are incredibly optimistic about the capabilities of the technology, its future applications and the ability to rapidly increase sales by demonstrating a clear advantage over PEEK and titanium."

Additional information about the Company's complete line of products may be found at www.amedica.com.

About Amedica Corporation:
Amedica is an innovative spine and orthopaedic implant and device manufacturing and distribution company that provides advanced surgical applications including silicon nitride ceramic technologies. The company's platform technologies represent a new standard for implants and biologics based on superior performance, safety and efficacy. Amedica is a privately held, private equity backed company founded in 1996 by internationally recognized orthopaedic surgeons and ceramicists. The company is ISO 13485 certified, its spine products are FDA cleared, CE marked, and sold in ten countries. Amedica Corporation is based in Salt Lake City, UT.

Media Contact
Stacey Holifield / Heather McIntyre
Schwartz MSL
(781) 684-0770
amedica@schwartzmsl.com


'/>"/>
SOURCE Amedica Corporation
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Specialty Silicone Fabricators Inaugurates New State-of-the-Art Facility in Paso Robles
2. RMANJ Research Demonstrates That Egg Freezing Prior To IVF Yields Positive Outcomes Without Increasing Risk Of Aneuploidy
3. Isis Pharmaceuticals Demonstrates The Potential Of Single-Stranded RNA-Like Antisense Technology To Activate The RNAi Pathway
4. Chimerixs Broad Spectrum Antiviral Therapeutic, CMX001, Demonstrates Potential To Mitigate BK Virus Associated End-Organ Disease In Clinical Study
5. Cancer Cell Article Demonstrates First Definitive Evidence for Targeting of Pol I as New Approach to Cancer Therapy
6. LIVE VIA SATELLITE: Physician Demonstrates New Medical Technology to Combat Back Pain without Major Surgery
7. Six-Year Follow-Up Data for SPRYCEL®? (dasatinib) 100 mg Once Daily Demonstrates 71 Percent Overall Survival in Patients with Chronic-Phase Chronic Myeloid Leukaemia Resistant or Intolerant to Imatinib
8. Polaris Group Lead Therapeutic Candidate ADI-PEG 20 Demonstrates Potential Anticancer Activity in Various Metastatic Sarcomas and Bladder Cancers That Are Deficient in Key Metabolic Protein, and Enhanced Effects with Combination Therapy in Melanoma
9. Philips demonstrates innovations in nuclear medicine imaging with a comprehensive portfolio of NM applications for IntelliSpace Portal
10. At SIIM 2012 Siemens Healthcare Demonstrates Departmental IT Solutions That Help Administrators Increase Access while Managing Costs
11. Flexions Lead Osteoarthritis Drug Candidate Demonstrates Significant, Prolonged Improvement in Pain and Function in Phase 2 Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... 12, 2017 West Pharmaceutical Services, Inc. ... for injectable drug administration, today announced that it will ... on Thursday, October 26, 2017, and will follow with ... expectations at 9:00 a.m. Eastern Time. To participate on ... The conference ID is 94093362. ...
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... , Oct. 4, 2017  According to the Centers for Disease ... end of October . PhysicianOne Urgent Care is helping communities across ... Westchester, NY , by offering no-cost* flu shots through the end ... mandated by certain health insurance regulations. ... The best time to get a flu shot is by the end ...
Breaking Medicine Technology:
(Date:10/12/2017)... ... October 12, 2017 , ... ... that we intend to develop to enable prevention of a major side effect ... hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed ...
(Date:10/12/2017)... ... 2017 , ... HMP , a leader in healthcare events and education, today ... Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & ... award competition recognizes editorial and design excellence across a range of sectors. This year’s ...
(Date:10/12/2017)... ... 12, 2017 , ... On Saturday, October 21, the Health & Wellness Center ... to raise money for the American Heart Association Heart Walk. Teams of up to ... together to keep their treadmills moving for 5 hours. Treadmills will start at 7:00 ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations ... literacy software tool, and the Cancer Patient Education Network (CPEN), an independent professional ... announce a new strategic alliance. , As CPEN’s strategic partner, HLI will ...
(Date:10/12/2017)... Miramar, FL (PRWEB) , ... October 12, 2017 ... ... is presenting the latest in wound care advancements to physician colleagues, skilled nursing ... lecture is titled, "Navigating the Treacherous Waters of Wound Care." , "At many ...
Breaking Medicine News(10 mins):