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Silicon Nitride Demonstrates Statistical Superior Osteointegration and Anti-infective Biomaterial Properties
Date:9/13/2012

SALT LAKE CITY, Sept. 13, 2012 /PRNewswire/ -- Amedica Corporation, a spinal and reconstructive implant manufacturer, announced today the publication of two peer-reviewed studies conducted at Brown University that demonstrate the superior osteointegration and bacterial-resistant properties of its proprietary Silicon Nitride (Si3N4) biomaterial when compared to poly-ether-ether-ketone (PEEK) or titanium (Ti). In related news, the company also announced the expansion of biomaterial property claims for its line of FDA 510(k) cleared interbody fusion devices.

Spine and orthopedic surgeons have historically relied on allograft bone, metal and plastic implants to aid in spine fusions and joint replacements. Implants have traditionally been comprised of materials that are resistant to host immune mechanisms and systemic antibiotics, creating an environment for significant bacterial growth. As a result, functional implants can become colonized with bacteria, which may reduce fusion rates or cause serious infection. Treating implant-related infection is costly and generally requires extensive repeat surgery that may extend suffering and disability for patients.

The in-vitro data from the journal article titled, "Decreased Bacteria Activity on Si3N4 Surfaces Compared with PEEK or Titanium," which appears in the International Journal of Nanomedicine 2012:7 1-12 reports that Silicon Nitride is far less vulnerable to bacterial colonization (S. epidermidis, S. aureus, P. aeruginosa, E. coli and Enterococcus) than PEEK and titanium. Additionally, because of the positive surface charge, nanostructure and hydrophilic nature of Silicon Nitride, there was also rapid adherence of fibronect
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SOURCE Amedica Corporation
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