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Silence Therapeutics to Receive $1.9m Milestone Payment as Pfizer and Quark Commence Phase II Trial
Date:7/30/2008

t further specific targets using Silence Therapeutics' proprietary AtuRNAi technology.

Iain Ross, Chairman and CEO of Silence Therapeutics, commenting on today's announcement said, "It is great news that our partners Quark and Pfizer are continuing to make good clinical progress with RTP-801i-14, a compound which we discovered together in our collaboration with Quark. The commencement of the first Phase II clinical trial utilizing our chemistry is a very significant milestone for Silence, and the advancement of this compound represents a further strong validation of our proprietary AtuRNAi technology."

The Company also announces today that its operating company Silence Therapeutics AG has been awarded a research grant from the German Federal Ministry of Education and Research. The BioChancePlus grant program provides individual grants to support innovative research initiatives in Germany. The grant, which totals €1.5 million over three years, was awarded to Silence Therapeutics AG in recognition of the company's pioneering research and development projects in the field of RNAi.

About Silence Therapeutics plc (http://www.silence-therapeutics.com)

Silence Therapeutics plc (AIM: SLN) is a leading European RNAi focused biotechnology company. RNAi can selectively 'silence' genes linked to the onset of disease. RNAi is a Nobel Prize winning technology and one of the most promising areas of drug discovery and development today.

Silence Therapeutics has developed a platform of novel short interfering RNA ('siRNA') molecules, AtuRNAi, which provide a number of advantages over conventional siRNA molecules, including increased stability against nuclease degradation. In addition, the Company has developed a proprietary systemic delivery system, AtuPLEX. This system enables the functional delivery of siRNA molecules to targeted diseased tissues and cells, while increasing their bio
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SOURCE Silence Therapeutics plc
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