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Silence Therapeutics and InteRNA Technologies Sign Collaboration to Develop Novel microRNA Therapeutics
Date:9/11/2011

>, said: "We are pleased to be collaborating with InteRNA, and it is in our interest to broaden the potential value of our AtuPLEX™ delivery system as a vehicle to modify gene expression using different oligonucleotide classes, alongside our continuing focus on our internal siRNA therapies. Functional delivery into target cells is one of the greatest challenges facing most nucleic acid therapies.  Silence remains committed to the development of its AtuPLEX™ and other delivery systems including DACC and DBTC as it seeks to overcome these challenges."  

Dr Roel Schaapveld, Chief Executive Officer of InteRNA Technologies, said: "We are very excited about this collaboration with Silence. Working with AtuPLEX™ and the experienced team at Silence fits perfectly in our strategy to address the delivery challenge of RNA based therapeutics upon systemic administration. AtuPLEX™ may significantly contribute to the efficacy of several miRNA drug candidates in our pipeline that have shown to reduce tumor growth in vivo and as such supports further development of these drug candidates towards the clinic."

Notes for editors                    

About Silence Therapeutics plc (http://www.silence-therapeutics.com)

Silence Therapeutics plc (AIM: SLN) is a leading biotechnology company dedicated to the discovery, development and delivery of targeted, systemic RNA interference (RNAi) therapeutics for the treatment of serious diseases. Silence offers one of the most comprehensive short interfering RNA (siRNA) therapeutic platforms available today based on a strong intellectual property portfolio and large clinical safety database. Silence's clinical siRNA product pipeline is one of the broadest in the industry. The Company possesses m
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SOURCE Silence Therapeutics Plc
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3. Silence Therapeutics Issued New U.S. Patent Covering Fundamental RNA Interference Technology Currently in Several Clinical Trials
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