Navigation Links
Silence Therapeutics Signs siRNA Delivery Collaboration With Top 10 Pharma Company
Date:9/26/2011

LONDON, September 27, 2011 /PRNewswire/ --

Silence Therapeutics plc (AIM: SLN) ("Silence"), a leading RNA interference (RNAi) therapeutics company, today announces that it has entered into an agreement with one of the world's leading global pharmaceutical companies to investigate the application of Silence's proprietary DACC delivery technology for intravenous delivery of short interfering RNA sequences ("siRNAs") to the pulmonary vascular endothelium.

Under the terms of the agreement, Silence's partner will provide Silence with specific siRNAs, which Silence will formulate with its DACC delivery system. Silence and its partner will undertake in vitro and in vivo studies of the DACC formulated siRNAs developed under the agreement and select lead candidates for further evaluation. Financial terms were not disclosed.

DACC is a novel lipid delivery system that includes Silence's proprietary lipid AtuFect and is used to embed siRNAs into a multiple lipid bi-layer structure. Whilst closely related to the AtuPLEX™ delivery system used in Atu027, Silence's lead oncology candidate in Phase I trials, DACC has significantly different properties on a physiochemical and pharmacological level. The DACC delivery system is incorporated in Atu111, Silence's preclinical development candidate for the treatment of acute lung injury, and enables functional, highly specific and efficient delivery of RNAi therapeutics to the pulmonary vascular endothelium. In preclinical models, the DACC delivery system has demonstrated highly focused delivery to lung tissue and sustained knockdown of the desired target gene expression in this particular cell type. Of note, the DACC delivery sys
'/>"/>

SOURCE Silence Therapeutics Plc
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Silence Therapeutics Announces Issuance of Japanese Patent for Screening Therapeutics Against Key Pathway Associated with Cancer and Other Diseases
2. Silence Therapeutics and InteRNA Technologies Sign Collaboration to Develop Novel microRNA Therapeutics
3. Silence Therapeutics Receives Notice of Allowance for New U.S. Patent Covering Novel Small Interfering RNA (siRNA) Delivery Technology
4. Silence Therapeutics Phase I Atu027 Data Accepted for Presentation at the American Society of Clinical Oncology 2011 Annual Meeting
5. Silence Therapeutics Issued New U.S. Patent Covering Fundamental RNA Interference Technology Currently in Several Clinical Trials
6. Silence Therapeutics Provides Year-end Update
7. Silence Therapeutics Issued New Patents Covering siRNA Sequences for RNA Interference Therapeutics
8. Silence Therapeutics and AstraZeneca Extend siRNA Development Collaboration
9. Silence Therapeutics to Merge with Intradigm Corp to Create Leading RNAi Therapeutics Company
10. Silence Therapeutics to Receive $1.9m Milestone Payment as Pfizer and Quark Commence Phase II Trial
11. Silence Therapeutics Announces Board Changes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014  Decision Resources Group finds that ... States will increase to a value of ... driven by expansion in the large direct energy device ... be increasingly adopted due to the advantages they offer ... key findings from Decision Resources Group,s coverage of the ...
(Date:12/19/2014)... Ky. , Dec. 18, 2014 Baptist Health ... States to receive full Atrial Fibrillation with Electrophysiology ... Care (SCPC). Atrial fibrillation is the most common ... that in some cases can lead to stroke and possible ... United States have atrial fibrillation and the numbers ...
(Date:12/19/2014)... and LYON, France , Dec. 19, ... LLY ) and Adocia (Euronext Paris: FR0011184241 – ADOC) ... an ultra-rapid insulin, known as BioChaperone Lispro, for treatment ... BioChaperone Lispro relies on Adocia,s proprietary BioChaperone® technology and ... and Adocia will develop BioChaperone Lispro with the goal ...
Breaking Medicine Technology:U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3
(Date:12/20/2014)... Today, Balfleet.com, one of the most outstanding dressmakers ... off on its Mother of the Bride Dresses ... the bride dresses from Balfleet.com feature gorgeous looks and ... takes pride in providing high quality dresses to its ... discounts on our mother of the bride dresses, and ...
(Date:12/19/2014)... (PRWEB) December 20, 2014 Sweetdressy.com ... market, has introduced its newest selection of cheap prom ... are very popular in the world and clients can ... , Meanwhile, these prom dresses feature cool cuts and ... $200 now, targeting the middle-end market. Discount shipping costs ...
(Date:12/19/2014)... CA (PRWEB) December 19, 2014 ... corporation dedicated to developing educational events, tools and ... Rouxbe Cooking School , the world’s leading ... the prescription every human being needs: Culinary Rx. ... plant-based cooking course, Culinary Rx, scheduled for debut ...
(Date:12/19/2014)... Eufaula, Oklahoma, located just 9 miles ... state’s largest lake with more than 600 miles of ... a little more than 3,000 residents, hosted its annual ... 6th of December. , Featuring Santa, Christmas lights and ... on Main Street. Narconon Arrowhead’s parade float participated ...
(Date:12/19/2014)... (PRWEB) December 20, 2014 The Medspa ... new injectable filler from respected cosmetic brand Juvéderm. Voluma ... naturally with age. The Medspa at Hendrick is pleased ... in skin care technology to its clients. , Voluma ... to be FDA-approved to treat the mid-face and cheek ...
Breaking Medicine News(10 mins):Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2Health News:Cheap Prom Dresses Online Now at Sweetdressy.com 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 3Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 4Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 2Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 3Health News:Breakthrough New Injectable Dermal Filler Voluma XC Offered by The MedSpa at Hendrick 2
... ... a common technology infrastructure for Policy, Compliance, Risk, SOX, Internal Audits and IT ... ... -- MetricStream, Inc. (“MetricStream”), the market leader in the enterprise-wide Governance, Risk ...
... (NYSE Alternext: ULU), a specialty pharmaceutical company ... and oral care products, today announced it has entered into ... at a price per share of $0.14 pursuant to a ... of approximately $1.5 million. , Investors will also receive warrants ...
... Mass., Nov. 12 Cequent Pharmaceuticals, a pioneer in ... to prevent and treat human disease, has announced that ... application with the U.S. Food and Drug Administration (FDA). ... candidate, targets beta-catenin, a key oncogene implicated in the ...
... Nov. 12 Mary Elizabeth Derig, of Seattle, Washington, ... Edition for her outstanding contributions and achievements in the ... ) , ABOUT MARY ELIZABETH ... an extensive career as a Registered Nurse including work ...
... (NYSE: ABT ) announced today a definitive agreement to ... antibody to Nerve Growth Factor (NGF), expanding the company,s pain ... a novel biologic in Phase I clinical trial development that ... released at sites of tissue damage and inflammation, and plays ...
... ... Mary Alexander will present during Class Action/Mass Torts session discussing tainted food products , ... San Francisco, CA (PRWEB) November 12, ... product law firms in the nation, will take the podium during the 48th Annual Consumer ...
Cached Medicine News:Health News:Amedisys Selects MetricStream for Integrated Enterprise-wide GRC 2Health News:ULURU Inc. to Raise $1.5 Million in Registered Direct Offering 2Health News:Cequent Files its First IND with FDA: CEQ508, a tkRNAi Drug Candidate in Oncology 2Health News:Cequent Files its First IND with FDA: CEQ508, a tkRNAi Drug Candidate in Oncology 3Health News:Cequent Files its First IND with FDA: CEQ508, a tkRNAi Drug Candidate in Oncology 4Health News:Mary Elizabeth Derig Recognized by Strathmore's Who's Who Worldwide Publication 2Health News:Abbott to Acquire Novel Investigational Biologic to Treat Chronic Pain 2Health News:California Consumer Attorney Mary Alexander to Present at 48th Annual COAC Convention 2
... microdermabrasion systems offer many features that add ... you time and money. Because our MegaPeel ... to use and maintain, you spend your ... microdermabrasion equipment. MegaPeel microdermabrasion systems are available ...
... the Clareon to practices that require an ... and efficacy. The versatility of the Clareon ... range of treatments that would typically require ... to worry about obsolescence because the Clareon ...
... perfect mix of powerful, versatile, and innovative ... Palomar StarLux® Pulsed Light and Laser System.,With ... compact base unit so theres no ... treatments., You can choose among Laser, Intense ...
... Many experts say the ... eliminating,vibratory or lateral movement of ... the mechanism of,the ARC-H II ... of the tip is,restricted to ...
Medicine Products: