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Silence Therapeutics Receives Notice of Allowance for New U.S. Patent Covering Novel Small Interfering RNA (siRNA) Delivery Technology
Date:8/3/2011

data showed dose-dependent increases in both siRNA and lipid levels, suggesting no evidence of drug accumulation during repeat treatment. Additionally, the maximum tolerated dose for Atu027 has yet to be reached, further supporting the tolerability of the treatment. These findings provide broad support for AtuPLEX as a safe and effective siRNA delivery technology with the potential to overcome the well-known delivery challenges associated with RNAi therapeutics.

AtuPLEX is the delivery technology incorporated in a number of Silence's partnered and internal RNAi therapeutic candidates. In addition, Silence's non-exclusively partnered DACC delivery system also incorporates the proprietary AtuFect lipid that is the subject of this notice of allowance.  

"The AtuPLEX and DACC delivery systems are key assets for Silence and for our current and future partners," stated Mr. Herrmann. "This latest intellectual property protection for our growing portfolio strengthens our ongoing business development activities that are focused on partnering Atu027 and also our world class delivery systems for individual genes or specific disease areas."

Silence Therapeutics is proactively building and strengthening its global, diverse and competitive intellectual property portfolio. This provides the Company and its partners with a strong proprietary position in the RNAi therapeutics space. The Company expects to make significant further progress in reinforcing its patent portfolio during 2011. At present, Silence's global patent portfolio contains issued patents and pending applications covering strategic areas of RNAi therapeutic development. These include multiple proprietary siRNA delivery technologies, potent siRNA sequences specific for high-value disease targets and key RNAi sequence and chemical modifications.

 

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Related medicine technology :

1. Silence Therapeutics Phase I Atu027 Data Accepted for Presentation at the American Society of Clinical Oncology 2011 Annual Meeting
2. Silence Therapeutics Issued New U.S. Patent Covering Fundamental RNA Interference Technology Currently in Several Clinical Trials
3. Silence Therapeutics Provides Year-end Update
4. Silence Therapeutics Issued New Patents Covering siRNA Sequences for RNA Interference Therapeutics
5. Silence Therapeutics and AstraZeneca Extend siRNA Development Collaboration
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