Navigation Links
Silence Therapeutics Receives Notice of Allowance for New U.S. Patent Covering Novel Small Interfering RNA (siRNA) Delivery Technology
Date:8/3/2011

LONDON, August 3, 2011 /PRNewswire/ --

Silence Therapeutics plc (AIM: SLN) ("Silence" or the "Company"), a leading global RNA interference (RNAi) therapeutics company, announces that the United States Patent and Trademark Office has issued the Company a notice of allowance on a patent application directed to the fundamental technology involved in AtuPLEX™, one of Silence's proprietary small interfering RNA (siRNA) delivery systems. The allowable subject matter is directed to AtuFect, the specific proprietary lipid that serves as the basis for the AtuPLEX delivery system, and provides proprietary protection for one of the RNAi industry's most clinically advanced and promising delivery technologies. These claims will cover the delivery system incorporated in Silence's lead clinical compound, Atu027, as well as a number of the Company's other RNAi therapeutic candidates.

"This is a highly valuable patent. Not only does it provide direct protection for AtuPLEX, one of the most advanced and exciting solutions addressing the challenge of delivering siRNAs, but also adds key layers of protection for our pipeline of RNAi therapeutics, including our lead RNAi therapeutic candidate, Atu027," said Max Herrmann, Chief Financial Officer of Silence Therapeutics."This notice of allowance follows the recent presentation of data from our ongoing clinical study of Atu027 at the 2011 American Society of Clinical Oncology conference which showed that the treatment, and therefore the AtuPLEX delivery technology, is safe and well-tolerated in all patients."

At the 2011 American Society of Clinical Oncology annual meeting, Silence presented interim Phase I clinical study results that showed promising antitumor activity associated with Atu027, as well as demonstrating that the treatment is well tolerated with no observed dose-limiting toxicities or evidence of cytokine activation. Favorable pharmacokinetic
'/>"/>

SOURCE Silence Therapeutics Plc
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Silence Therapeutics Phase I Atu027 Data Accepted for Presentation at the American Society of Clinical Oncology 2011 Annual Meeting
2. Silence Therapeutics Issued New U.S. Patent Covering Fundamental RNA Interference Technology Currently in Several Clinical Trials
3. Silence Therapeutics Provides Year-end Update
4. Silence Therapeutics Issued New Patents Covering siRNA Sequences for RNA Interference Therapeutics
5. Silence Therapeutics and AstraZeneca Extend siRNA Development Collaboration
6. Silence Therapeutics to Merge with Intradigm Corp to Create Leading RNAi Therapeutics Company
7. Silence Therapeutics to Receive $1.9m Milestone Payment as Pfizer and Quark Commence Phase II Trial
8. Silence Therapeutics Announces Board Changes
9. Recent siRNA Research Publications Support Silence Therapeutics Combined Development Approach
10. Video: Actress and New Mom Keri Russell Joins PKIDs to Launch Silence the Sounds of Pertussis Campaign
11. Actress and New Mom Keri Russell Joins PKIDs to launch Silence the Sounds of Pertussis Campaign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... AARP Foundation today announced it has established a relief ... cold weather that has gripped much of the nation. AARP ... so to support these emergency relief efforts AARP and AARP ... mean up to $500,000 in aid. The matching program will ...
(Date:1/15/2014)... 15, 2014 Shire plc (LSE: SHP, NASDAQ: ... Fair Trading (OFT) approval condition to the announced tender offer for ... As a result of the waiver, the transaction is ... the tender offer on January 24, 2014 following the currently scheduled ...
(Date:1/15/2014)... , Jan. 15, 2014  In an unprecedented effort to curb ... in ambulances and other transport vehicles, an advanced and portable UV ... personnel for the first time. In order to ... these deadly pathogens, West Palm Beach Fire ...
Breaking Medicine Technology:AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Superbugs No Longer Ride In Rescue Vehicles 2
(Date:7/9/2014)... policing injection drug users in Russia might contribute ... A study, conducted by researchers from Boston University ... with St. Petersburg Pavlov State University, sought to ... health outcomes of a cohort of HIV-positive people ... who were arrested by police were more likely ...
(Date:7/9/2014)... release is available in French . ... in 14 year old teens, including brain structure and function, ... accuracy who will go on to develop binge drinking within ... conscientiousness, and other variables such as life events and a ... binge drinking. Whether or not the child had had ...
(Date:7/9/2014)... the world have been linked to an emerging ... the National Institute for Mathematical and Biological Synthesis ... contribute. , In a series of mathematical ... hemorrhage of internal organs in frogs, could cause ... they are exposed to the virus every few ...
(Date:7/9/2014)... The National Institute of Allergy and Infectious Diseases ... has launched an early-stage clinical trial of CRS3123, ... Clostridium difficile ( C. difficile ) infection. ... agent that inhibits C. difficile growth while sparing ... will enroll up to 30 healthy men and ...
(Date:7/9/2014)... poor printing on prescription labels handed out by ... errors in taking medication, according to new research ... National Institute for the Blind)., The study, published ... found that labels on prescription medications dispensed by ... for legibility. , By simply following recommended guidelines ...
Breaking Medicine News(10 mins):Health News:BU researchers relate arrests with HIV risk environment 2Health News:What drives a child to abuse alcohol? 2Health News:Study predicts ranavirus as potential new culprit in amphibian extinctions 2Health News:NIH launches Phase I clinical trial of novel drug to treat Clostridium difficile infection 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2
... in four Pakistani adults aged 15 years and above is ... link with hypertension and diabetes//. ,The study has ... similarities among the people's food habits and lifestyle in the ... that excess weight and obesity are a major health problem ...
... Researchers at the University of California, San Diego (UCSD) ... white blood cells that play key roles// in inflammation ... navigate to sites of infection and inflammation. These findings ... and inflammatory diseases in patients. ,The research, reported ...
... incidents, particularly those resulting in harm, warns a study ... the current system, which relies on voluntary reporting, may ... accurate information on the extent of harm resulting from ... common in hospitals, and many of them lead to ...
... resident doctors of All India Institute of Medical Sciences ... //in Lok Sabha on Thursday intensified with five more ... Anil Sharma, spokesman of the AIIMS Resident Doctors' Association, ... duty and services at AIIMS.' – Dr Sharma said. ...
... Australia, AMA Vice-President, Dr Choong-Siew Yong, today cautioned people ... take extra care during periods of smoke haze. ... anyone’s health, but that's particularly true for people with ... ,'Large airborne particles such as embers can irritate ...
... "Pascal" Norris died in July. The cause of his death ... an instrument maker and made African drums, and it is ... leather. ,Anthrax is caused by bacterium Bacillus anthracis ... goats but humans exposed to infected animals can also be ...
Cached Medicine News:Health News:Researchers Discover Internal Compass of Immune Cells 2Health News:Hospitals Miss Most Patient Safety Incidents 2Health News:Asthma Warning As Bushfires Burn 2
... The Sysmex pocH-100i is the first Sysmex ... low daily testing requirements. With its small ... differential from just 15 L of whole ... any small healthcare site including the emergency ...
... a self-contained, compact, easy-to-use, bedside automated cell ... Ichor system provides a hematology profile of ... platelet aggregation within five minutes. The test ... is added to both an EDTA baseline ...
... pacemaker family, which includes the world's ... the most advanced pacemaker technology available, ... the first and only U.S. commercially ... fibrillation (AF). The AF Suppression algorithm ...
... catheters that are controlled by an ... console processes the refrigerant, which when ... the catheter, creates cryogenic temperatures., ,The ... touch-screen interface. From this interface, the ...
Medicine Products: