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Silence Therapeutics Issued New U.S. Patent Covering Fundamental RNA Interference Technology Currently in Several Clinical Trials
Date:2/23/2011

tual property news, Silence also announces the issuance of United States patent 7,893,243, titled "Composition and Methods of RNAi Therapeutics for Treatment of Cancer and Other Neovascularization Diseases," by the United States Patent and Trademark Office (USPTO).  This issued patent is broadly directed to a double stranded, double blunt ended siRNA sequence against the validated cancer target vascular endothelial growth factor (VEGF).  VEGF has been demonstrated to play an important role in the underlying causes of various cancers including abnormal angiogenesis and uncontrolled cell division.  The active pharmaceutical ingredient covered by the issued patent is a potent 25mer siRNA, with or without chemical modification, further demonstrating Silence's continued ability to secure meaningful intellectual property protection for its portfolio of 25mer sequences.  

Silence Therapeutics is executing a proactive strategy to continue to build and strengthen a global, diverse and competitive intellectual property portfolio that provides the Company and its partners with a strong proprietary position in the RNAi therapeutics space.  The Company believes that it will continue to make significant progress in these efforts as it expects additional RNAi patents to be issued in Japan, the United States and Europe during 2011.  At present, Silence's global patent portfolio contains issued patents and pending applications covering strategic areas of RNAi therapeutic development including multiple proprietary siRNA delivery technologies, potent siRNA sequences specific for high-value disease targets and key RNAi sequence and chemical modifications.

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About Silence Therapeutics plc (www.silence-therapeutics.com)

Silence Therapeutics plc (AIM: SLN) is a leading global biotechnology company dedicated to the discovery, development and deli
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