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Silence Therapeutics Announces Board Changes
Date:7/1/2008

s of Silence Therapeutics plc.

Iain Rugheimer has been on the Board of Silence Therapeutics plc (formerly SR Pharma plc) since 1995, was briefly Chairman of the Group in 2004, and has been Chairman of the Audit Committee for a number of years.

Commenting on the changes, Iain Ross, Chairman, Board of Directors of Silence Therapeutics, commented, "I would like to thank Iain Rugheimer for his contribution over the years and especially for his personal support and advice over the last four years as we have sought to transform the Company. He will be missed and, on behalf of the Board, I wish him every success in the future. I am delighted to take this opportunity to welcome Annette Clancy and Jerry Randall to the Board. Both of them bring a wealth of experience and contacts in the industry and with the Company at such an exciting stage of its development, I am pleased that we have been able to attract two such talented individuals."

Information concerning the new directors:

Annette Clancy

No current or past directorships.

Jeremy Anthony Philip Randall

Current Directorships:

Sinclair Pharma plc

Kinneir Dufort Limited

Avantis (UK) Ltd

Maggiore Ventures Limited

Operation Smile (UK) Limited

Past Directorships:

Pharmadiligence Limited

Crisp Group Limited

There are no other matters to report under schedule 2(g) of the AIM Rules in respect of either director.

Notes to Editors:

About Silence Therapeutics plc (http://www.silence-therapeutics.com)

Silence Therapeutics plc (AIM: SLN) is a leading European RNAi focused biotechnology company. RNAi can selectively 'silence' genes linked to the onset of disease. RNAi is a Nobel Prize winning technology and one of the most promising areas of drug discovery and development today.

Silence Therapeutics has developed a platform of novel short
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SOURCE Silence Therapeutics plc
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