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Sihuan Pharmaceutical Collaborates with NeuroVive to Develop Two Innovative Cardio-cerebral Vascular Products in China
Date:11/20/2012

HONG KONG, Nov. 20, 2012 /PRNewswire/ -- Sihuan Pharmaceutical Holdings Group Ltd. (HKEx: 0460) ("Sihuan Pharmaceutical" or the "Company"), a leading pharmaceutical company with the largest cardio-cerebral vascular ("CCV") drug franchise in China's prescription market, is pleased to announce that it has entered into a collaboration agreement with NeuroVive Pharmaceutical AB ("NeuroVive"), a leading international mitochondrial pharmaceutical development company, to develop two innovative products, CicloMulsion® and NeuroSTAT®, which are used for the treatment of heart reperfusion injuries and traumatic brain injuries respectively.

Pursuant to the collaboration agreement, NeuroVive will grant Sihuan Pharmaceutical an exclusive license to develop, market and sell CicloMulsion® and NeuroSTAT® in China, as well as the intellectual property rights and knowhow in connection with the products to pass clinical trials. Both CicloMulsion® and NeuroSTAT® reach international standards, and they are currently undergoing the third and second phases of clinical trials respectively. Both medical products contain cyclosporine A, which is mainly used for the treatment of heart reperfusion injuries and traumatic brain injuries. By protecting the mitochondria of cells, CicloMulsion® and NeuroSTAT® ensure that energy production is preserved and the normal regenerative mechanisms of damaged cells can act to repair and maintain the cells. Therefore, the two products act to prevent the destruction of the mitochondria in damaged cells and the cascade of intracellular biochemical events that lead to secondary tissue damage following a traumatic injury. As there are currently no approved pharmaceutical treatment options for these types of injuries, the two products have enormous market potential. The current market size of exclusive drug products with similar efficacy is over RMB1 billion. According to MENET, the CCV market amounts to approxim
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SOURCE Sihuan Pharmaceutical Holdings Group Ltd.
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