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Sihuan Pharmaceutical Achieves Important R&D Breakthrough
Date:3/11/2012

e-clinical trials such as acute anti-hypertensive trials and chronic administration anti-hypertensive trials. In pre-clinical pharmacokinetic/pharmacodynamic ("PK /PD") studies, Tylerdipine Hydrochloride reported long-term efficacy. Its safety has also been ensured in animal testing.

According to the METNET and National Health Services Survey, over 200 million Chinese suffer hypertension, a number that grows by more than 3 million each year. Overall treatment costs exceed RMB40.0 billion per year which included over RMB30.1 billion for anti-hypertensive drugs in 2011 (according to IMS data), constituting a huge market with enormous potential. Calcium channel blockers are the best-selling type of anti-hypertension drugs. Tylerdipine Hydrochloride differentiates itself from other Calcium channel blockers by its higher efficacy and ability to treat hypertension while protecting important organs such as the heart and kidneys, a function unseen in similar products. The Company expects that once registered, this product would be its first international innovative drugs and become a flagship product in the anti-hypertension therapeutic area and further contribute to Sihuan's leading position in the CCV market.

Dr. Che Fengsheng, Chairman and CEO of Sihuan Pharmaceutical, said, "We are pleased to announce the recent acceptance of our application for Tylerdipine Hydrochloride by the SFDA and believe it, in addition to the success we have had with Apapenem Carbapenems, represents a significant achievement for our R&D team. R&D is an important contributor as we further expand and optimize our product portfolio. We continue to invest in the development of innovative and first-in-market drugs and explore other growth sectors.  One particular interest is in the field of biopharmaceuticals, represented by therapeutic antibodies, a key focus area of China's 12th Five-Year Plan. The Company has established a world-class R&D team in biopharmaceu
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SOURCE Sihuan Pharmaceutical Holdings Group Ltd.
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