Navigation Links
Significant potential of late- and mid-stage Novartis hematology portfolio to be showcased at upcoming ASH meeting
Date:12/2/2009

T interval. ECGs should be performed at baseline, seven days after initiation, periodically as clinically indicated, and following dose adjustments. Correct hypokalemia or hypomagnesemia prior to administration and monitor periodically.

Significant prolongation of the QT interval may occur when Tasigna is inappropriately taken with food, and/or strong CYP3A4 inhibitors and/or medicinal products with a known potential to prolong QT. Therefore, co-administration with food must be avoided and concomitant use with strong CYP3A4 inhibitors and/or medicinal products with a known potential to prolong QT should be avoided. The presence of hypokalemia and hypomagnesemia may further enhance this effect.

Sudden deaths

There were sudden deaths reported in the safety population and in the expanded access program. Ventricular repolarization abnormalities may have contributed to their occurrence.

Elevated serum lipase

Caution is recommended in patients with a history of pancreatitis. Check serum lipase levels monthly or as clinically indicated.

Hepatotoxicity

Serum bilirubin and hepatic transaminases

The use of Tasigna may result in elevations in bilirubin, AST/ALT, and alkaline phosphatase. Hepatic function tests should be checked monthly or as clinically indicated.

Electrolyte abnormalities

Tasigna can cause hypophosphatemia, hypokalemia, hyperkalemia, hypocalcemia, and hyponatremia. Correct electrolyte abnormalities prior to initiating Tasigna and monitor periodically during therapy.

Hepatic impairment

Nilotinib exposure is increased in patients with impaired hepatic function. A lower starting dose is recommended for patients with mild to severe hepatic impairment and QT interval should be monitored closely.

Drug interactions

The concomitant use of QT prolonging drugs a
'/>"/>

SOURCE Novartis
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

Related medicine technology :

1. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
2. DEFLUX(R) Significantly Reduces Urinary Tract Infections in Children With Vesicoureteral Reflux
3. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
4. Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS)
5. Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial
6. Largest Study to Date Shows Significant Reductions in Risks of Blood Clots and Reintervention With CYPHER(R) Sirolimus-eluting Coronary Stent Compared to Taxus Stent
7. Phase III Clinical Trial in Newly Diagnosed Multiple Myeloma Stopped Early Due to Highly Significant Efficacy Advantage of VELCADE(R) (Bortezomib) for Injection Based Therapy Across All Endpoints
8. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
9. DOV 21,947 Demonstrates Significant Body Weight and BMI Reductions in Drug- Compliant Subjects in Phase Ib Clinical Study
10. FASgen Announces Significant Milestone in Its Cancer Drug Development Program
11. New Data Reveal Topical Divigel(R) (estradiol gel) 0.1% Significantly Reduces Frequency and Severity of Hot Flashes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... , May 23, 2013  Every day, their baby ... air to his lungs. April and Bryan Gionfriddo ... predictions weren,t true. "Quite a few doctors said ... alive," says April Gionfriddo , about her ... Anything that would work, we would take it and run ...
(Date:5/23/2013)... , May 23, 2013   Direct to ... mastectomy is an appropriate option for many women ... surgically reduce their breast cancer risk, or with ... expansion process and a second surgery to insert ... the same surgery as mastectomy can be a ...
(Date:5/23/2013)... TEL AVIV, Israel , May 23, 2013 ... of BrainTech Israel 2013 , Israel,s ... take place on October 14 th -15 th in ... 2 nd most innovative city in the world by ... the "Start-up Nation." BrainTech Israel 2013 will showcase ...
Breaking Medicine Technology:Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 3Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 4Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 2Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 3Israel Brain Technologies Announces Israel's 1st International Brain Technology Conference 2Israel Brain Technologies Announces Israel's 1st International Brain Technology Conference 3
(Date:5/23/2013)... May 23, 2013 Memorial Day Focus ... Chaplains have been a part of the U.S. Military ... like those preceding it, these men and women will ... United States of America. As veterans transition to ... migration to the workplace chaplaincy world. , Marketplace ...
(Date:5/23/2013)... doubt it when a woman harried by hot flashes ... new study published online in Menopause , the ... confirm with objective tests that what these women say ... some studies showed that hot flashes were related to ... even though there was a relationship between hot flashes ...
(Date:5/23/2013)... leading journal Science published an article about ... and an important starting point for further Alzheimer,s research. ... researcher at VIB and KU Leuven in collaboration ... and scientists at Janssen Pharmaceutica, Beerse, also tested ... Their results were different, as were those of two ...
(Date:5/23/2013)... “Talk. They Hear You.” a new national ... talk to children as young as nine years old ... by the Substance Abuse and Mental Health Services Administration ... SAMHSA’s 2013 National Prevention Week—an annual health observance dedicated ... and mental health issues. , SAMHSA’s latest report on ...
(Date:5/23/2013)... PA (PRWEB) May 23, 2013 ... Teaching Site, offering a comprehensive babysitting training course for ... program was developed by Indianapolis pediatrician Dr. Patricia Keener ... the care of an adult sitter who didn’t know ... well-rounded youth development program with a medical basis that ...
Breaking Medicine News(10 mins):Health News:Memorial Day Focus Spotlight on Military Chaplains Transitioning in the Marketplace 2Health News:Memorial Day Focus Spotlight on Military Chaplains Transitioning in the Marketplace 3Health News:New insights contradict promising Alzheimer's research 2Health News:New Campaign to Help Parents Talk to Younger Children About the Dangers of Underage Drinking 2Health News:Susquehanna Health Offers Safe Sitter Course for Tweens and Teens 2Health News:Susquehanna Health Offers Safe Sitter Course for Tweens and Teens 3
... how cocaine corrupts the brain and becomes addictive. These findingsthe ... cocaine rewardwere published in Science on October 15. ... treating those addicted to the drug. Led by ... Neuroscience at Mount Sinai School of Medicine and first author ...
... The US Department of Defense (DOD) has awarded a ... Research and the University of Cincinnati to further develop ... severe brain injury. Management of severe brain trauma ... critical first few hours and days after an injury. ...
... , MONDAY, Oct. 18 (HealthDay News) -- Canadian ... the so-called swine flu -- to be very severe this ... of 50, especially those with chronic health conditions, get immunized ... results of blood tests given to 1,127 people in the ...
... Institute has awarded a $4.37 million grant to Jeffrey ... to advance a recent scientific laboratory discovery into a ... under the American Recovery and Reinvestment Act, will help ... by Toretsky and his team a critical step ...
... Texas (October 18, 2010) The latest colorectal ... Gastroenterology,s (ACG) 75th Annual Scientific meeting in San ... evidence that suggests significant disparity in colorectal cancer ... the first in a series of studies investigating ...
... Antonio, Texas (October 18, 2010) Investment in screening ... 50 and 64, is needed to reduce the costs ... the results of a new study, "Cost-Savings to Medicare ... unveiled today at the American College of Gastroenterology,s (ACG) ...
Cached Medicine News:Health News:Mount Sinai researchers discover why cocaine is so addictive 2Health News:Feinstein Institute to share $5M US Department of Defense grant 2Health News:H1N1 Unlikely to Cause Flu Pandemic in 2010-11: Analysis 2Health News:$4.37 million NCI grant accelerates recent laboratory finding in Ewing's sarcoma 2Health News:$4.37 million NCI grant accelerates recent laboratory finding in Ewing's sarcoma 3Health News:Notable racial disparities in diagnosis, treatment and outcomes of colorectal cancer 2Health News:Notable racial disparities in diagnosis, treatment and outcomes of colorectal cancer 3Health News:Investment in CRC screening targeting pre-medicare population could cut medicare treatment costs 2
... The BD Macro-Vue RPR (Rapid ... and Tear-drop Tests are nontreponemal testing ... syphilis described in A Manual of ... in this manual are the most ...
Rapid Plasma Reagin (RPR) set is a non-treponemal flocculation test that is,used for the qualitative and semi-quantitative determination of reagin,antibodies in serum or plasma from persons with syph...
For use as a quality assurance reagent in assays detecting IgG antibody to mumps virus (mumps IgG), IgG antibody to measles (Rubeola) virus (measles IgG) and IgG antibody to varicella zoster virus (V...
... For use as a ... detecting IgG antibody to Toxoplasma ... to rubella virus (rubella IgG), ... IgG) and IgG antibody to ...
Medicine Products: