Navigation Links
Significant Pre-Clinical Data in Acute Lung Injury
Date:9/9/2012

LONDON, September 10, 2012 /PRNewswire/ --

Silence Therapeutics plc (AIM: SLN) ("Silence" or "the Company"), a leading RNA interference (RNAi) therapeutics company is pleased to announce that recent data in pre-clinical models demonstrated the efficacy of Atu111 in acute lung injury. Atu111 targets the endothelial expression of Angiopoietin-2 (Ang-2), an antagonistic ligand of Tie-2 signalling, which is implicated in progressing endothelial dysfunction in the context of disease pathogenesis for acute lung injury or sepsis.

The study, which evaluated the use of Atu111 in a preclinical Streptococcus pneumoniae model of acute lung injury, was conducted by Ricerca Biosciences, a US-based clinical research organisation. The trial demonstrated a 90% survival benefit with the use of Atu111 in the presence of antibiotics when compared to an untreated control cohort. By contrast, antibiotic therapy alone achieves only a 20% survival benefit over untreated.

To further evaluate the findings, Silence is pleased to announce the successful start of a research alliance with the laboratory of Prof. Dr. med. Hermann Haller, Director of Nephrology and Chairman of the Department of Internal Medicine at the Medizinische Hochschule Hannover MHH (Hannover Medical School, Germany) to evaluate the therapeutic potential of Atu111 in preclinical models for acute lung injury and sepsis. In collaboration with Dr. Sascha David, lead investigator in this project, Atu111, a novel RNAi therapeutic drug candidate based on Silence´s proprietary DACC formulation will be investigated in various pre-clinical models assessing the therapeutic value of Atu111 treatment on inhibiting progression of acute lung injury or sepsis.

A first proof-of-concept with Atu111 in a model for septic/systemic shock revealed superior survival in
'/>"/>

SOURCE Silence Therapeutics Plc
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Epigenomics Presents Significant Opportunities for Investment and Product Development, According to New Biotech Market Research
2. Latest Drug Sales Data: Loss of Patent Protection Has Significant Effect, According to Drugs.com
3. Patient Advocate Foundation Receives Significant Support to Aid Non-Squamous Non-Small Cell Lung Cancer Patients through the Co-Pay Relief Program
4. Cambrex Announces Significant New Supply Agreement
5. Wound Care Management Market to 2018 - Advanced Wound Care Modalities and an Expanding Patient Base Create Significant Growth Opportunities in Emerging Countries
6. Huntzinger Management Group, Inc., (HMG) Reporting Significant Growth in 2012
7. Pressure BioSciences Patented PCT Platform Shown to Significantly Improve Protein and DNA Detection in Multiple Studies
8. North Dakotas Stop-Sale System Achieves Significant Results In Battle Against Meth
9. Floridas Stop-Sale System Achieves Significant Results In Battle Against Meth
10. Nebraska Stop-Sale System Achieves Significant Results In Battle Against Meth
11. Texas Stop-Sale System Achieves Significant Results In Battle Against Meth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 2014 PuraMed BioScience ® , Inc., ... (OTC) medicinal and healthcare products, announced today that ... along with the name,s red and yellow logo. ... name MigraPure ®  going forward. The new ... natural migraine pain reliever will be reintroduced into ...
(Date:7/30/2014)... DUBLIN , July 30, 2014 ... the "Global and Chinese Aseptic Packaging Industry Report ... http://photos.prnewswire.com/prnh/20130307/600769 The Global and ... in-depth study on the current state of the global ... situation. The report provides a basic overview of ...
(Date:7/30/2014)... -- Stryker brand ambassadors Fred Funk and Hal ... Tour event near Minneapolis, MN , which begins ... Stryker is the official joint replacement products company of the PGA ... st through Sunday, August 3 rd , fans will be ... destination located in the Pioneer Press Expo tent located near the ...
Breaking Medicine Technology:PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 2PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 3Global and Chinese Aseptic Packaging Industry Report 2014 2Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 2Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 3Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 4Stryker Brand Ambassadors Fred Funk And Hal Sutton Set To Play At 3M Championship 5
(Date:7/30/2014)... DC (PRWEB) July 30, 2014 ... appreciation to U.S. Sens. Thad Cochran (R-MS) and ... for improvements in telemedicine coverage under Medicare, Medicaid ... and Wicker, both Mississippi Republicans, introduced the Telehealth ... to a House version, H.R. 3306, introduced by ...
(Date:7/30/2014)... The Institute for Integrative Nutrition (IIN), ... Arianna Huffington has joined as a guest speaker and is ... Training Program . , Arianna Huffington is the chair, president, ... blogging site that won a Pulitzer Prize in 2012 for ... was included on the Forbes “Most Powerful Women” list of ...
(Date:7/30/2014)... 2014 Frozen shoulder (Adhesive capsulitis) affects 10-20 ... develop this nasty condition which occurs most frequently in people ... up to two and half years if not treated. , ... with good reason: it can render your shoulder so stiff, ... if you aren't in too much pain to get dressed ...
(Date:7/30/2014)... Amy Norton HealthDay Reporter ... a garden might help soothe the agitation that commonly strikes ... 17 past studies, British researchers found evidence that watering plants, ... some dementia patients, anxiety. The study authors cautioned that ... subject to study -- and the evidence of a benefit ...
(Date:7/30/2014)... three months or more as babies have a ... cardiovascular and metabolic diseases, according to research from ... Louis. , "This study shows that birthweight and ... later," said Molly W. Metzger, PhD, assistant professor ... the study with Thomas W. McDade, PhD, of ...
Breaking Medicine News(10 mins):Health News:ATA Applauds Senators’ Push for Federal Telemedicine Improvements 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 2Health News:Arianna Huffington Joins Integrative Nutrition as a Guest Speaker 3Health News:Good News for Diabetics Suffering from Frozen Shoulder 2Health News:Good News for Diabetics Suffering from Frozen Shoulder 3Health News:Good News for Diabetics Suffering from Frozen Shoulder 4Health News:Gardens a Center of Calm for People With Dementia 2Health News:Gardens a Center of Calm for People With Dementia 3Health News:Birthweight and breastfeeding have implications for children's health decades later 2
... Doctors' representative body BMA Scotland has urged the government to ... to 18. According to the BMA chairman//, Dr Peter Terry, ... ,Though the Health Minister Andy Kerr considers this as a ... public discussion before it can be enforced. Incidentally, Scotland blazed ...
... died after catching bird flu from wild swans//. ,The ... that they had occurred earlier this year. They also went on ... flu that were being passed on from the wild birds. ... village in Azerbaijan, and are believed to have caught the lethal ...
... and extent of physical exertion has taken a perplexing ... children. //The bottom line of the study scoffs at ... in children and child-obesity rates. The finding hovered around ... conditions, which have a bearing on child obesity, rather ...
... has sounded alarm over rising cocaine consumption in Western ... in Afghanistan this year reversing the decline witnessed last ... world body urged European Union governments not to ignore ... often denying their addiction, and drug abuse by celebrities ...
... from the Food and Drug Administration for its "abbreviated new ... posting on the FDA site. ,The website reported ... solution with strength of 10mg per ml. The new drug ... transcriptase inhibitors. It stops the replication of the HIV virus ...
... Central Reserve Police Force (CRPF), India's premier paramilitary force, have ... according to an internal survey. ,"We had conducted the ... become drug dependent and found 426 alcohol and drug addicts," ... survey was started in February and conducted across the 250,000-strong ...
Cached Medicine News:Health News:Four Deaths Due To Bird Flu Caught From Wild Birds 2
The Achieva CV brings the power of CMR into routine clinical practice, so you can do more in Cardiovascular MR....
The AutoSet Respond offers ResMeds unique AutoSet algorithm and product quality in a convenient, affordable model. The AutoSet algorithm responds to the patients pressure needs on a breath-by-breath ...
... Spirit is the premium APAP device in ... The AutoSet algorithm responds to the patients ... flow generator stores and reports comprehensive clinical ... AutoSet devices combine integrated humidification and a ...
These products are primarily for use with paediatric patients and for patients with difficult veins....
Medicine Products: