Navigation Links
Significant Anti-Tumor Activity of NKTR-102 in Patients With Refractory Solid Tumors; Interim Data Published in ASCO 2008 Proceedings
Date:5/16/2008

Nektar's Technology Enables First-Ever PEGylation of a Small Molecule with

Demonstrated Therapeutic Activity

SAN CARLOS, Calif., May 16 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR) announced initial results today from a Phase 1 study of NKTR- 102, PEGylated irinotecan. The data shows significant anti-tumor activity in patients with refractory solid tumors. The study also demonstrates that Nektar's small molecule PEGylation technology produced an increase in SN38 exposure that was up to six-fold higher than the exposure previously reported with irinotecan at equivalent doses. SN38, a topoisomerase I inhibitor, is the active metabolite of irinotecan.

The ASCO abstract reports interim data on 27 of 32 patients in the first of three dose schedules from the Phase 1 trial.(1) Results for the first schedule (weekly x3 q4 weeks) found anti-tumor activity in 7 out of the total 32 patients evaluable for efficacy. Partial responses were confirmed in three patients, or 10% (greater than 30% tumor regression per RECIST), and other evidence of anti-tumor activity was confirmed in four patients, or 12% (tumor regression by more than 15% but less than 30% per RECIST, or significant biomarker evidence).

"This significant anti-tumor activity in a number of patients whose tumors have progressed on prior therapies makes NKTR-102 one of the most promising cancer drugs I have ever studied," said Daniel D. Von Hoff, M.D., lead Phase 1 investigator for NKTR-102, Physician-in-Chief at the Translational Genomics Research Institute and Chief Medical Officer for the Scottsdale Clinical Research Institute at Scottsdale Healthcare.

Nektar's proprietary PEGylation technology can enhance the properties of t
'/>"/>

SOURCE Nektar Therapeutics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
2. DEFLUX(R) Significantly Reduces Urinary Tract Infections in Children With Vesicoureteral Reflux
3. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
4. Vidaza Significantly Extends Overall Survival by 74% in Phase 3 Trial in Myelodysplastic Syndromes (MDS)
5. Nexavar Significantly Improved Overall Survival in Phase 3 Asia-Pacific Liver Cancer Trial
6. Largest Study to Date Shows Significant Reductions in Risks of Blood Clots and Reintervention With CYPHER(R) Sirolimus-eluting Coronary Stent Compared to Taxus Stent
7. Phase III Clinical Trial in Newly Diagnosed Multiple Myeloma Stopped Early Due to Highly Significant Efficacy Advantage of VELCADE(R) (Bortezomib) for Injection Based Therapy Across All Endpoints
8. Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia
9. DOV 21,947 Demonstrates Significant Body Weight and BMI Reductions in Drug- Compliant Subjects in Phase Ib Clinical Study
10. FASgen Announces Significant Milestone in Its Cancer Drug Development Program
11. New Data Reveal Topical Divigel(R) (estradiol gel) 0.1% Significantly Reduces Frequency and Severity of Hot Flashes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... , July 27, 2015  Attorney Advertising-- Bronstein, Gewirtz ... behalf of purchasers of the securities of AMAG ... -News).  Such investors are advised to contact ... Eitan Kimelman at info@bgandg.com ... AMAG and certain of its officers and/or directors ...
(Date:7/27/2015)... ALBANY, New York , July 27, 2015 ... Transparency Market Research "Bionics Market - Global Industry Analysis, Size, ... market was valued at USD 7.96 billion in 2014, growing ... account for USD 20.49 billion in 2021. The ... in the number of accidents, which is leading to paralysis ...
(Date:7/27/2015)... , July 20, 2015 Research and ... of the "D-dimer Testing Market - Global ... Forecast 2014 - 2022" report to their ... vitro diagnostics market is one of the fastest ... attributed to the improved health care awareness, preference ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Bronstein, Gewirtz & Grossman, LLC Announces Investigation of AMAG Pharmaceuticals Inc. 2Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 2Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 3Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 4D-dimer Testing Market - Global Industry Analysis 2015 2D-dimer Testing Market - Global Industry Analysis 2015 3
(Date:7/28/2015)... , ... July 28, 2015 , ... Nurses across all ... time, up to 57 million Americans may need mental health services (SAMHSA, 2013) and ... Psychiatric-mental health RNs are one of the largest workforces who provide care ...
(Date:7/28/2015)... ... July 28, 2015 , ... Want to improve your fitness level ... your easy chair? Luckily, there are plenty of back-friendly cardio exercises that are safe ... surgeon at Atlantic Spine Center . , It’s simply untrue that those ...
(Date:7/27/2015)... ... July 28, 2015 , ... Dr. Robert G. Schwartz ... practice has teamed up with Realief Neuropathy Centers in order to offer his patients ... the signs and symptoms of peripheral neuropathy. , Peripheral neuropathy is a disease caused ...
(Date:7/27/2015)... ... July 28, 2015 , ... ... as the sports medicine provider for the entire school district including Anderson County ... ACHS Athletic Director Rick Sallee, “Student safety and well-being are a top priority ...
(Date:7/27/2015)... , ... July 28, 2015 , ... The National ... inductee into the NAPW VIP Woman of the Year Circle. She is recognized with ... 200 operating Local Chapters, NAPW is the nation’s leading networking organization exclusively for professional ...
Breaking Medicine News(10 mins):Health News:American Psychiatric Nurses Association Transitions in Practice Certificate Program to Improve Mental Health Care Through Continuing Nursing Education 2Health News:American Psychiatric Nurses Association Transitions in Practice Certificate Program to Improve Mental Health Care Through Continuing Nursing Education 3Health News:American Psychiatric Nurses Association Transitions in Practice Certificate Program to Improve Mental Health Care Through Continuing Nursing Education 4Health News:Safe Cardio for Back Pain Sufferers 2Health News:Safe Cardio for Back Pain Sufferers 3Health News:Piedmont Physical Medicine & Rehabilitation, P.A. Partners with Realief® Neuropathy Centers to Offer Peripheral Neuropathy Laser Treatment 2Health News:KORT Physical Therapy Named Sports Medicine Provider for Anderson County School System 2Health News:KORT Physical Therapy Named Sports Medicine Provider for Anderson County School System 3Health News:NAPW Inducts Jane Simmons, Counseling Intern at Omar Bradley Middle School of the Northeast Independent School District , Into its VIP Woman of the Year Circle 2
... caffeine in coffee, tea or soft drinks increases blood ... may undermine efforts to control their disease, say scientists ... technology that measured participants glucose (sugar) levels on a ... psychologist at Duke and the lead author of the ...
... assisted living facility in violation of "Nicole,s Law" designed to ... protect vulnerable ... Atria Senior Living? That,s what members of the Campaign to Improve,Assisted ... facility at 15 Stevens Street in Andover was found in,violation of ...
... EPA campaign in January heightens awareness, tries to reduce ... an invisible radioactive gas that seeps into homes through ... monoxide poisoning, says the U.S. Environmental Protection Agency. , ... has designated January as National Radon Action Month. , ...
... people in Western society are suffering from auto-immune diseases. ... first important step in the search for targeted medicines. ... Universiteit Leuven joined forces and have elucidated the function ... They are the first to show that MALT1 ...
... how a particular family of diseases are passed down from ... severity of the disease differing widely. The research, funded by ... a child,s risk of developing a mitochondrial disease which can ... All human and animal cells contain many mitochondria, which are ...
... On January 23rd, Public,Citizen, a consumer group, filed ... and,Administration (FDA) requesting labeling changes for botulinum toxins,marketed ... and recorded studies in peer-reviewed journals have,documented the ... Surgery (ASAPS), the leading organization of board-certified,plastic surgeons ...
Cached Medicine News:Health News:Cutting caffeine may help control diabetes 2Health News:Activists Raise Alarm for Seniors, Deliver Carbon Monoxide Detectors to Atria Marland Place 2Health News:Radon Gas More Deadly Than Carbon Monoxide Poisoning 2Health News:A major step toward a more targeted treatment for auto-immune diseases? 2Health News:Mitochondrial 'bottleneck' cracked 2Health News:The American Society for Aesthetic Plastic Surgery Addresses the Safety of Botox 2
Keeler Professional Combi Retinoscope with new slimline handle and lithium or dry cell option....
300XL System, English (U.K. cord), 100-240 VAC....
Micro-mini fiber optic light....
Xenon technology achieves a higher efficiency than halogen light sources. Consequently they provide more light....
Medicine Products: